Results 111 to 120 of about 6,940,219 (310)

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Detection performance analysis of advanced direction time lightning detection system in China

Frontiers in Earth Science
In order to study the detection performance of the Advanced Direction Time Lightning Detection System (ADTD) over mainland China, the relationship between the detection efficiency (DE) and distance for ADTD sensor is analyzed using lightning location ...
Hualiang Zhu, Wenjing Pang, Fengjiao Chen, Fengjiao Chen, Miaomiao Zhang, Jing Wang, Zhichao Wang   +6 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Real-Time Acoustic Telemetry Buoys as Tools for Nearshore Monitoring and Management

Journal of Marine Science and Engineering
Acoustic telemetry monitoring for tagged sharks in nearshore waters has become an important tool for beach safety management; however, detection performance can vary widely in shallow, high-energy nearshore environments where management decisions are ...
James M. Anderson, Brian S. Stirling, Patrick T. Rex, Emily A. Spurgeon, Anthony McGinnis, Zachariah S. Merson, Darnell Gadberry, Christopher G. Lowe   +7 more
doaj   +1 more source

The influence of training status, age, and muscle fiber type on cycling efficiency and endurance performance. [PDF]

, 2013
The purpose of this study was to assess the influence of age, training status, and muscle fiber-type distribution on cycling efficiency. Forty men were recruited into one of four groups: young and old trained cyclists, and young and old untrained ...
Wiles, J., Hopker, J., Coleman, Damian A, Jobson, Simon A., Gregson, Hannah C, Wiles, Jonathan, Coleman, D., Gregson, H., Coleman, Damian A., Hopker, James G., Passfield, L., von der Haar, Tobias, Passfield, Louis, Von der Haar, T., Jobson, S., Gregson, Hannah C.   +15 more
core   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Energy Efficiency Board 2017 programs and operations report.

, 2018
Annual; Began with 2010; ceased with 2011.; At head of title: Connecticut Energy Efficiency ...
Connecticut. Energy Efficiency Board.
core  

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Evaluation of the efficiency of detection of bacterial DNA in milk and tissue samples from cattle, sheep, and goats by conventional and nested PCR targeting Com1, sod and Transposase IS1111 genes of Coxiella burnetii genome

Macedonian Veterinary Review
Q fever is a worldwide zoonosis, caused by Coxiella burnetii, an obligate intracellular bacterium that affects both humans and animals. The serious consequences on human health and the economic losses it causes, require the use of rapid, accurate, and ...
Konstantin Borisov Simeonov, Keytlin Venelinova Todorova, Petia Dinkova Genova-Kalou   +2 more
doaj   +1 more source