Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Method for Determining Iodine Activity Distribution in Activated Carbon Filter Cartridge Source
Journal of Isotopes, 2021 I-131 is an important artificial radionuclide and an important detection object in nuclear facilities. The current mainstream method is to use a uniformly distributed Ba-133 source instead of an iodine source to calibrate the I-131 detection instrument ...
KE Lianbao;XIA Wen;YE Hongsheng;SONG Xinpeng;XU Lijun;LIN Min;CHEN Kesheng
doaj
A combined approach of DNA metabarcoding collectively enhances the detection efficiency of medicinal plants in single and polyherbal formulations. [PDF]
Front Plant Sci, 2023 Travadi T +5 more
europepmc +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Belief or disbelief in feedback influences the detection efficiency of the feedback concealed information test. [PDF]
Front Psychol, 2022 Cheng J +4 more
europepmc +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
New Journal of PhysicsImperfect detection efficiency remains one of the major obstacles in achieving loophole-free Bell tests over long distances. At the same time, the challenge of establishing a common reference frame for measurements becomes more pronounced as the ...
Paweł Cieśliński +3 more
doaj +1 more source
A Method of Damage Detection Efficiency Enhancement of PZT Sensor Networks under Influence of Environmental and Operational Conditions. [PDF]
Sensors (Basel), 2022 Dziendzikowski M +5 more
europepmc +1 more source
FEBS Letters, EarlyView.Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley +1 more source
Differential Confocal Optical Probes with Optimized Detection Efficiency and Pearson Correlation Coefficient Strategy Based on the Peak-Clustering Algorithm. [PDF]
Micromachines (Basel), 2023 Wang Z, Wang T, Yang Y, Mi X, Wang J.
europepmc +1 more source