Results 101 to 110 of about 6,940,219 (310)

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Energy Efficiency Board 2018 programs and operations report.

, 2019
Annual; Began with 2010; ceased with 2011.; At head of title: Connecticut Energy Efficiency ...
Connecticut. Energy Efficiency Board.
core   +1 more source

Government Efficiency and Accountability Review Board - GEAR - Annual Report

, 2017
Annual Report for the Government Efficiency and Accountability Review (GEAR ...
Government Efficiency and Accountability Review Board
core   +2 more sources

Report of the Energy Efficiency Board. 2012.

, 2013
Annual; Began with 2010.; At head of title: Connecticut Energy Efficiency ...
Connecticut. Energy Efficiency Board.
core  

Structural network efficiency predicts conversion to dementia [PDF]

, 2016
OBJECTIVE: To examine whether structural network connectivity at baseline predicts incident all-cause dementia in a prospective hospital-based cohort of elderly participants with MRI evidence of small vessel disease (SVD).
Tuladhar, A.M., Norris, D.G., Norris, David G., Leeuw, F.E. de, Tuladhar, Anil M., Claassen, Jurgen A.H.R., Claassen, J.A., Markus, H.S., de Leeuw, Frank-Erik, Dijk, E.J. van, van Dijk, Ewoud, Lawrence, A., van der Holst, Helena, de Laat, Karlijn, van Norden, Anouk, van Uden, Ingeborg W.M., Kessels, R.P.C., Laat, K.F. de, Kessels, Roy P.C., Holst, H.M. van der, Rutten-Jacobs, L.C.A., Rutten-Jacobs, Loes C.A., Uden, I.W.M. van, Norden, A.G.W. van, Markus, Hugh S.   +24 more
core   +3 more sources

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Energy Efficiency Board. 2016 Programs and Operations Report.

, 2017
Annual; Began with 2010; ceased with 2011.; At head of title: Connecticut Energy Efficiency ...
Connecticut. Energy Efficiency Board.
core  

Exploring Online Novelty Detection Using First Story Detection Models [PDF]

, 2018
Online novelty detection is an important technology in understanding and exploiting streaming data. One application of online novelty detection is First Story Detection (FSD) which attempts to find the very first story about a new topic, e.g.
Wang, Fei, Robert J. Ross, Kelleher, John D., Fei Wang, John D. Kelleher, Ross, Robert J.   +5 more
core   +1 more source