Results 131 to 140 of about 860,624 (265)

Hierarchical Plasmonic Au@ZnO Chemosensor Enhanced the Sensitivity and Detection Limit of Pb²⁺ Metallic Ions. [PDF]

ACS Omega
Preeti K, Sharma SK.
europepmc   +1 more source

Kernel-phase detection limits

, 2019
The James Webb Space Telescope will offer high-angular resolution observing capability in the near-infrared with masking interferometry on NIRISS, and coronagraphic imaging on NIRCam & MIRI. Full aperture kernel-phase based interferometry complements these observing modes, probing for companions at small separations while preserving the telescope ...
Ceau, Alban, Mary, David, Greenbaum, Alexandra, Martinache, Frantz, Sivaramakrishnan, Anand, Laugier, Romain, N'Diaye, Mamadou, N’diaye, M.   +7 more
openaire   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

The offonome reveals on and off states of gene expression near the detection limit of RNA-seq. [PDF]

Sci Rep
Choi WY, Zhao X, Holt J, Jain R, Jo H, Hoadley KA, Hayes DN, Choi HY.   +7 more
europepmc   +1 more source

Low Detection Limit and High Sensitivity 2-Butanone Gas Sensor Based on ZnO Nanosheets Decorated by Co Nanoparticles Derived from ZIF-67. [PDF]

Nanomaterials (Basel), 2023
Zhang H, Zhao W, Meng F.
europepmc   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

A bioinspired self-powered optical tactile sensing system with ultrahigh sensitivity and ultralow detection limit. [PDF]

Nat Commun
Hou T, Chen C, Guo R, He S, Zi Y.
europepmc   +1 more source

Overcome low levels of detection limit and choice of antibody affects detection of lipoarabinomannan in pediatric tuberculosis. [PDF]

PLoS One, 2022
Amin AG, De P, Graham B, Jensen BL, Moreau E, Chatterjee D.   +5 more
europepmc   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

A high selectivity and low detection limit carbon monoxide sensor based on Au-GO/Co-ZnO composite material. [PDF]

Microsyst Nanoeng
Zhou T, Chen T, Qi Z, Sun J, Niu Z, Li X, Ma T, Kong X, Zhao L, Lin J, Luo B, Li Z.   +11 more
europepmc   +1 more source