Results 151 to 160 of about 4,854,135 (253)

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Monte carlo study of detection limit for gold nanoparticles within small animal sized object during benchtop X-ray fluorescence computed tomography. [PDF]

Sci Rep
Nepal N, Jayarathna S, Cho SH.
europepmc   +1 more source

Implementation of the surface gradiometer receive coils for the improved detection limit and sensitivity in the single-sided MPI scanner. [PDF]

Phys Med Biol, 2022
McDonough C, Pagan J, Tonyushkin A.
europepmc   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

The offonome reveals on and off states of gene expression near the detection limit of RNA-seq. [PDF]

Sci Rep
Choi WY, Zhao X, Holt J, Jain R, Jo H, Hoadley KA, Hayes DN, Choi HY.   +7 more
europepmc   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

A bioinspired self-powered optical tactile sensing system with ultrahigh sensitivity and ultralow detection limit. [PDF]

Nat Commun
Hou T, Chen C, Guo R, He S, Zi Y.
europepmc   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Limit Theory for Explosively Cointegrated Systems [PDF]

A limit theory is developed for multivariate regression in an explosive cointegrated system. The asymptotic behavior of the least squares estimator of the cointegrating coefficients is found to depend upon the precise relationship between the explosive ...
Peter C.B. Phillips, Tassos Magdalinos
core  

Hierarchical Plasmonic Au@ZnO Chemosensor Enhanced the Sensitivity and Detection Limit of Pb²⁺ Metallic Ions. [PDF]

ACS Omega
Preeti K, Sharma SK, Sharma SK.
europepmc   +1 more source