Results 171 to 180 of about 1,026,341 (311)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Improvement of Tunable Diode Laser Absorption System with a Novel Multipass Cell and Wavelet Transform

Journal of Measurement Science and Instrumentation, 2011
Combination of Tunable Diode Laser Absorption Spectroscopy（TDLAS）technique and multipass cell is an attractive approach for ultrahigh sensitive detection of trace gases.Theoretically,based on Beer-Lambert law,the longer optical path length and the larger
Hua XIA, Guo-jie TU, Tao PANG, Zhi-rong ZHANG, Bian WU, Feng-zhong DONG   +5 more
doaj  

Implementation of the surface gradiometer receive coils for the improved detection limit and sensitivity in the single-sided MPI scanner. [PDF]

Phys Med Biol, 2022
McDonough C, Pagan J, Tonyushkin A.
europepmc   +1 more source

Limit-Defying μ‑Total Analysis System: Achieving Part-Per-Quadrillion Sensitivity on a Hierarchical Optofluidic SERS Sensor

Optofluidic sensors have accelerated the growth of smart sensor platforms with improved sensitivity, reliability, and innovation. In this article, we report the integration of a surface-enhanced Raman scattering (SERS) material consisting of silver ...
Subhavna Juneja (8457555), Alan X. Wang (3012876), Boxin Zhang (5820008)   +2 more
core   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Lateral deflection-based optimization achieves sub-picometer detection limit. [PDF]

Microsyst Nanoeng
Jiang Q, Qiao B, Ding X, Xu Y, Hu H.
europepmc   +1 more source

A handheld luminometer with sub-attomole limit of detection for distributed applications in global health

Luminescence is ubiquitous in biology research and medicine. Conceptually simple, the detection of luminescence nonetheless faces technical challenges because relevant signals can exhibit exceptionally low radiant power densities.
Charlton, Chris, Gómez-Sjöberg, Rafael, Wiener, Diane M, Elledge, Susanna, Lebel, Paul, Saha, Senjuti, Huynh, Emily, Puccinelli, Robert, Phelps, Maíra, Jacobsen, Axel, Mondal, Prasenjit, Jeyakumar, Ilakkiyan, Tato, Cristina M   +12 more
core   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

The offonome reveals on and off states of gene expression near the detection limit of RNA-seq. [PDF]

Sci Rep
Choi WY, Zhao X, Holt J, Jain R, Jo H, Hoadley KA, Hayes DN, Choi HY.   +7 more
europepmc   +1 more source