Results 201 to 210 of about 1,026,341 (311)

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Rankings of tuberculosis antibiotic treatment regimens are sensitive to spatial scale, detection limit, and initial host bacterial burden. [PDF]

J Theor Biol
Michael CT, Budak M, Maiello P, Kracinovsky K, Rodgers M, Tomko J, Lin PL, Flynn J, Linderman JJ, Kirschner D.   +9 more
europepmc   +1 more source

Detection limit of electron spin resonance for Japanese deciduous tooth enamel and density separation method for enamel-dentine separation. [PDF]

J Radiat Res, 2022
Oka T, Takahashi A, Koarai K, Kino Y, Sekine T, Shimizu Y, Chiba M, Suzuki T, Osaka K, Sasaki K, Shinoda H.   +10 more
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

High-Sensitivity, Low Detection Limit, and Fast Ammonia Detection of Ag-NiFe₂O₄ Nanocomposite and DFT Study. [PDF]

Nanomaterials (Basel)
Hao X, Sun Y, Liu Z, Jiao G, Zhang D.
europepmc   +1 more source

Rethinking COVID-19 test sensitivity-a strategy for improving the detection limit. [PDF]

Pan Afr Med J, 2021
Akhtar MK, Leung RK, Khan G.
europepmc   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Highly stable bismuth-chloride perovskite X-ray direct detectors with an ultralow detection limit. [PDF]

Chem Sci
Chen H, Han Q, Qin H, Shen Y, Lv H, Liu Y, Du L, Wang Y, He Y, Ning W.   +9 more
europepmc   +1 more source

Determination of X-ray detection limit and applications in perovskite X-ray detectors. [PDF]

Nat Commun, 2021
Pan L, Shrestha S, Taylor N, Nie W, Cao LR.   +4 more
europepmc   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source