Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
RNA‐Cleaving Deoxyribozyme Sensor for Nucleic Acid Analysis: The Limit of Detection
, 2010 Yulia V. Gerasimova +2 more
openalex +1 more source
Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source
Low Detection Limit and High Sensitivity 2-Butanone Gas Sensor Based on ZnO Nanosheets Decorated by Co Nanoparticles Derived from ZIF-67. [PDF]
Nanomaterials (Basel), 2023 Zhang H, Zhao W, Meng F.
europepmc +1 more source
Design of Pitch Limit Detection Algorithm for Submarine
, 2016 Jong-Yong Park, Nakwan Kim, Yong-Ku Shin
openalex +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
The offonome reveals on and off states of gene expression near the detection limit of RNA-seq. [PDF]
Sci RepChoi WY +7 more
europepmc +1 more source
Label-free, ultra-low detection limit DNA biosensor using high quality optical microcavity functionalized by DNA tetrahedral nanostructure probes. [PDF]
Nanophotonics, 2023 Wan H +6 more
europepmc +1 more source
Currents: Ambient thermal dissociation generates fragments outside the mass spectrometer | Tag for improved limits of detection with ESI MS | Mixed-bed ion-exchange resin for enhanced MudPIT | Quantitative proteomics method for fast events | A feedback strategy leads to high proteome coverage | Potential biomarkers for Sjögren’s syndrome | Dinosaur and mastodon fossils yield evidence of collagen with proteomics methods [PDF]
, 2007 openalex +1 more source
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source