Results 71 to 80 of about 561,010 (268)

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Detection Probability and Bias in Machine-Learning-Based Unoccupied Aerial System Non-Breeding Waterfowl Surveys

Drones
Unoccupied aerial systems (UASs) may provide cheaper, safer, and more accurate and precise alternatives to traditional waterfowl survey techniques while also reducing disturbance to waterfowl.
Reid Viegut, Elisabeth Webb, Andrew Raedeke, Zhicheng Tang, Yang Zhang, Zhenduo Zhai, Zhiguang Liu, Shiqi Wang, Jiuyi Zheng, Yi Shang   +9 more
doaj   +1 more source

Use of visual surveys and radiotelemetry reveals sources of detection bias for a cryptic snake at low densities

Ecosphere, 2020
Transect surveys are frequently used to estimate distribution and abundance of species across a landscape, yet a proportion of individuals present will be missed because either they were out of view and unavailable for detection or they were available ...
Scott M. Boback, Melia G. Nafus, Amy A. Yackel Adams, Robert N. Reed   +3 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Range‐wide population size of the lesser prairie‐chicken: 2012 and 2013

Wildlife Society Bulletin, 2014
We flew aerial line‐transect surveys to estimate the range‐wide population size of lesser prairie‐chickens (Tympanuchus pallidicinctus) in the Great Plains, United States in 2012 and 2013.
Lyman McDonald, Grant Beauprez, Grant Gardner, Jim Griswold, Christian Hagen, Fawn Hornsby, David Klute, Sean Kyle, James Pitman, Troy Rintz, Doug Schoeling, Bill Van Pelt   +11 more
doaj   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Timing matters: cloud cover and date influence probability of detecting nesting Chimney Swifts (Chaetura pelagica)

Avian Conservation and Ecology, 2019
One third of bird species in North America need immediate conservation action. Effective management and recovery actions for species of conservation concern require accurate methods of monitoring species occurrence that limit the incidence of ...
Elisabeth F. Purves, C. Myles. Falconer, Douglas C. Tozer, Kristyn Richardson   +3 more
doaj  

Factors affecting the occupancy of sloth bear and its detection probability in Parsa-Koshi Complex, Nepal. [PDF]

Ecol Evol, 2023
Sharma HP, Katuwal HB, Bhattarai BP, Bhandari S, Adhikari D, Aryal B, Tamang K, Nepali A, Kc S, Baral BD, Devkota S, Koirala S, Mandal DN, Regmi S.   +13 more
europepmc   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source