Results 61 to 70 of about 562,156 (267)

A generalized method to determine detectability of rare and cryptic species using the ornate box turtle as a model

open access: yesWildlife Society Bulletin, 2011
Estimates regarding population parameters are often based on data from surveys. To ensure that such estimates are as accurate as possible, it is important to know the detectability resulting from the particular survey method used.
Jeanine M. Refsnider   +5 more
doaj   +1 more source

On detection probabilities of link invariants

open access: yes
Abstract We prove that the detection rate of n-crossing alternating links by many standard link invariants decays exponentially in n, implying that they detect alternating links with probability zero. This phenomenon applies broadly, in particular to the Jones and HOMFLYPT polynomials and integral Khovanov homology.
Kelomäki, Tuomas   +4 more
openaire   +3 more sources

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

Electroshocking as a survey technique for stream‐dwelling amphibians

open access: yesWildlife Society Bulletin, 2012
Electroshocking has long been employed as a survey technique for fish, but has not been directly tested against rock rolling as a survey methodology for stream‐dwelling amphibians.
John O. Cossel Jr.   +2 more
doaj   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

open access: yesMolecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi   +14 more
wiley   +1 more source

Evaluation of an automated recording device for monitoring forest birds

open access: yesWildlife Society Bulletin, 2012
Monitoring of forest songbirds via auditory detections during point surveys can be enhanced by using preprogrammed recording devices. During May–July 2008, we compared boreal forest bird surveys conducted with SM‐1 bird song recorders (Wildlife Acoustics,
Lisa A. Venier   +4 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

open access: yesMolecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur   +11 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

On the Form of the Optimal Measurement for the Probability of Detection [PDF]

open access: yesInternational Journal of Theoretical Physics, 2015
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

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