Results 51 to 60 of about 561,010 (268)

The hidden side of diversity: Effects of imperfect detection on multiple dimensions of biodiversity

open access: yesEcology and Evolution, 2021
Studies on ecological communities often address patterns of species distribution and abundance, but few consider uncertainty in counts of both species and individuals when computing diversity measures. We evaluated the extent to which imperfect detection
Aline Richter   +3 more
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

open access: yesMolecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera   +11 more
wiley   +1 more source

Table Detection via Probability Optimization [PDF]

open access: yes, 2002
In this paper, we define the table detection problem as a probability optimization problem. We begin, as we do in our previous algorithm, finding and validating each detected table candidates. We proceed to compute a set of probability measurements for each of the table entities.
Yalin Wang 0001   +2 more
openaire   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

open access: yesMolecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain   +10 more
wiley   +1 more source

On the Form of the Optimal Measurement for the Probability of Detection [PDF]

open access: yesInternational Journal of Theoretical Physics, 2015
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire   +1 more source

Accounting Fraud: An Estimation of Detection Probability [PDF]

open access: yesSSRN Electronic Journal, 2011
Financial statement fraud (FSF) is costly for investors and can damage the credibility of the audit profession. To prevent and detect fraud, it is helpful to know its causes. The binary choice models (e.g. logit and probit) commonly used in the extant literature, however, fail to account for undetected cases of fraud and thus present unreliable ...
Wuerges, Artur Filipe Ewald   +1 more
openaire   +3 more sources

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

open access: yesMolecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner   +14 more
wiley   +1 more source

On detection probabilities of link invariants

open access: yes
Abstract We prove that the detection rate of n-crossing alternating links by many standard link invariants decays exponentially in n, implying that they detect alternating links with probability zero. This phenomenon applies broadly, in particular to the Jones and HOMFLYPT polynomials and integral Khovanov homology.
Kelomäki, Tuomas   +4 more
openaire   +2 more sources

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