Results 121 to 130 of about 913,709 (314)
Building-Level Detection Threshold of SARS-CoV-2 in Wastewater. [PDF]
Microbiol Spectr, 2023 Rondeau NC, Rose OJ, Alt ER, Ariyan LA, Elikan AB, Everard JL, Schreier AR, Tessler ME, Tulinsky GH, Vo JR, Ray CA, Yang CY, Miranda JL, Mailloux BJ. +13 moreeuropepmc +1 more sourceDevelopmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley +13 morewiley +1 more sourceFinding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer +10 morewiley +1 more sourceMOA-2010-BLG-311: A planetary candidate below the threshold of reliable detection [PDF]
, 2012 peer reviewedWe analyze MOA-2010-BLG-311, a high magnification (A_max>600) microlensing event with complete data coverage over the peak, making it very sensitive to planetary signals.Southworth, J., Beatty, T. G., Gorbikov E., Southworth, J, Donatowicz, J., Kains, N, Monard, L. A. G., BOZZA, Valerio, Wouters D., Burgdorf, Mj, Scarpetta G., Gould, A., Schonebeck, F, Southworth J., Saito, To., Thornley, G, Bramich, D. M., MANCINI, Luigi, Kerins, E.; id_orcid, Schafer, S., Williams, Andrew, Kains, N., Gaudi, B., Tristram, Pj, Itow Y., Harris, P., Kubas, D., Christie, G. W., Gaudi B. S., Furusawa, K., Abe, F., Dominis Prester D., Poleski, R, Proft S., Shvartzvald Y., Saito T., Martin, R., DePoy, D., Natusch, T., Lee, C.-U., Yee, J. C., Tsapras, Y., Depoy, Dl, Wyrzykowski, L, Rattenbury N. J., Albrow, M. D., Fukui, A, Coutures, C, Liebig C., Allen, W, Gaudi, Bs, Corrales, E., Batista, V., Schoenebeck, F., Shvartzvald, Y., Prester, D., Polishook, D, Park B. -G., Hung, L-, Sumi, T., Hung, L., Hardis S., Browne P., Ricci, Davide, Browne, P., Cole, Aa, Thornley G., Batista V., Maoz D., Liebig, C., Lee C. -U., Lee, C. U., Scarpetta, G, Fouque, P, Suzuki, D., Rattenbury, N. J., Ling, Ch, Brillant, S., Cole, A., Tsapras, Y, Gorbikov, E, Rahvar, S, Rattenbury, Nj, Wambsganss J., Suzuki D., Gerner, T, Bos M., Zub, M., Pietrzynski, G., Burgdorf, M., Wambsganss, J, Hessman, F. V., Udalski, A, Cole A. A., Han, C., Pogge, R. W., van Saders, J., Kaspi, S., Szymanski, M. K., Harris, P, Bachelet, E., Shappee, B., Sahu, K. C., Bennett, C. S., Horne K., Moorhouse D., Fouque, P., Henderson, C., Snodgrass, C, Beaulieu, J. -P., Dong S., Calchi Novati, S, Hessman, Fv, Kerins, E, Rattenbury, N., Sahu, K., Bowens-Rubin, R., Alsubai, K., Jorgensen, U. G., Novati, S., Henderson C. B., Caldwell, Jar, Horne, K, Snodgrass C., Beatty, Tg, Caldwell, J. A. R., Shporer A., Furusawa, K, Wyrzykowski, Ł., Shappee, B, Saito, T, Bramich, Dm, Dieters, S., Furusawa K., Sweatman, W., Bozza, V., The Collaboration, M., Masuda, K., Proft, S., Dong, S., Fouque P., Donatowicz J., Marquette, J. B., Hung, L. -W., Botzler, C. S., Wambsganss, J., Kubiak, M., Schafer, S, Donatowicz, J, Sahu, Kc, Alsubai, Ka, Alsubai K. A., Beaulieu, J. P., Sweatman, Wl, Mathiasen, M., Beatty, T., Wouters, D., Hinse, Tc, Jorgensen, Ug, Caldwell, J., Bennett D. P., Cassan, A., Monard, L. A G, Christie G. W., Yock, P., Hessman, F., Van Saders J., Mathiasen, M, Surdej, J., Sumi, T, Botzler, Cs, Freeman, M., Chote, P., Marquette, J.-B., Street, R. A., Van Saders, J, Gould, A, Harris P., Bond I. A., Drummond, J., Steele, I. A., Jorgensen, U., Yee J. C., Prester, D. Dominis, Depoy D. L., Bennett C. S., Drummond J., Rahvar S., Bond, I. A., Poleski R., Botzler, C., Drummond, J, Han C., Polishook D., Park, B., Park, B-, Soszy��ski, I., Jørgensen, U. G., Bowens-Rubin R., Bozza, V, Snodgrass, C., Bennett, D. P., Penny, M. T., Finet, François, Itow, Y., Albrow M. D., Surdej J., Burgdorf M. J., Maoz, D., Udalski, A., Mccormick, J, Yee, J., Bachelet, E, Surdej, J, Dieters, S, Surdej, Jean, Gerner T., Soszynski, I., Kaspi, S, Browne, P, Kerins E., Tristram, P., Fouqu��, P., Bramich, D., Monard, Lag, Calchi Novati S., Caldwell, J. A R, Itow, Y, Szymanski M. K., Yee, Jc, Cassan, A, Park, B. -G., Bennett, D., Coutures, C., Horne, K., Bond, Ia, Shporer, A., Shappee B., Penny, Mt, Miyake, N, Brillant S., CALCHI NOVATI, Sebastiano, Nola, M., Bennett, Cs, Kubas, D, Schaefer, S., Pietrzy��ski, G., Lee, C. -U., Williams, A., Finet, F., Park, B. G., Beaulieu J. -P., Bowens Rubin, R., Miyake, N., Williams, A, Finet, F, Kubiak M., Bozza V., Hung L. -W., Harpsoe, K., Saito, T., Menzies, J. W., Zellem, R., Schafer S., Sumi T., Wada, K, Gould A., Dodds P., Wada K., Bachelet E., Chote, P, Gerner, T., Dodds, P., Bennett, C., Marquette J. -B., Zellem R., Abe F., Menzies J. W., Ulaczyk, K, Yock, P. C M, Calchi Novati, S., Natusch T., Scarpetta, G., Wambsgans, J., Greenhill J., Tristram P. J., Ulaczyk, K., Dominis Prester, D., Ulaczyk K., Saito, To, Polishook, D., Sullivan, D. J., Pogge, R., Martin R., Greenhill, J, Menzies, Jw, Ricci, D, Sahu K. C., Hinse, T., Soszynski I., Skowron, J, Moorhouse, D., Beaulieu, J.-P., DePoy, D. L., Miyake N., Wyrzykowski, [Unknown], Shporer, A, Mathiasen M., Skowron, J., Alsubai, K. A., Pogge, Rw, Chote P., Rahvar, S., Bennett, Dp, Bowens-Rubin, R, Soszynski, I, Hinse T. C., Dieters S., Skowron J., Han, C, Penny, M., Matsubara Y., Penny M. T., Kaspi S., Abe, F, Shvartzvald, Y, Corrales, E, Kubiak, M, Wyrzykowski, ��., Burgdorf, M. J., Kubas D., Lee, C-, Hung, L.-W., Lee, C., SCARPETTA, Gaetano, Pietrzyński, Grzegorz, Christie, G., Bos, M, Liebig, C, Saito, T.o., Pietrzynski, G, Tsapras Y., Dodds, P, Harpsoe K., Park, B.-G., Yock P. C. M., Bowens-Rubin, Rachel, Harpsoe, K, Corrales E., Tristram, P. J., Botzler C. S., Polishook, David, Street R. A., Bramich D. M., Henderson, Cb, Mancini, L., Ricci, D., Fukui, A., Cassan A., Nola, M, Szymanski, M., Albrow, M., McCormick J., Wouters, D, Moorhouse, D, Matsubara, Y, Brillant, S, Hundertmark M., Steele I. A., Fukui A., Menzies, J., Gaudi, B. S., Proft, S, Maoz, D, Freeman M., Cole, A. A., Ohnishi, K, Nola M., Sullivan, D., Hundertmark, M, Ling, C., Szymanski, Mk, Ohnishi K., Hardis, S, Coutures C., Greenhill, J., Hundertmark, M., Batista, V, Dominis Prester, D, Schonebeck F., Henderson, C. B., Harpsøe, K., Sullivan D. J., Klein, N., Hung, L. W., Street, R., Freeman, M, Schonebeck, F., Szyma��ski, M. K., Zellem, R, Suzuki, D, Pietrzynski G., Ohnishi, K., Klein N., Zub, M, Williams A., Wyrzykowski L., Mancini, L, Sullivan, Dj, Steele, Ia, Natusch, T, Kains N., Poleski, R., Beaulieu, J., Bos, M., Dominik, M., Beaulieu, J-, Hinse, T. C., Matsubara, Y., Yock, P. C. M., Martin, R, Dominik, M, Hessman F. V., Monard L. A. G., Hardis, S., Caldwell J. A. R., Wyrzykowski, L., Christie, Gw, Wada, K., Masuda, K, Beatty T. G., Finet F., Gorbikov, E., Marquette, J-, Masuda K., Thornley, G., Ricci D., Pogge R. W., Marquette, J., Street, Ra, Yock, Pcm, Marquette, J. -B., Monard, L., Sweatman W. L., Kerins, E., Albrow, Md, Allen, W., Ling, C. H., Zub M., Sweatman, W. L., Bond, I., McCormick, J., Dominik M., Ling C. H., Dong, S, Udalski A., Jorgensen U. G., Dong, Subo, Allen W., Klein, N, Mancini L., Steele, I. +461 morecore +1 more sourceLongitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer
Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht +14 morewiley +1 more sourceSubspace discovery for video anomaly detection [PDF]
, 2010 PhDIn automated video surveillance anomaly detection is a challenging task. We address
this task as a novelty detection problem where pattern description is limited
and labelling information is available only for a small sample of normal instances.
Tziakos, Ioanniscore A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz +9 morewiley +1 more source
