Results 121 to 130 of about 2,087,074 (350)

Suppression of intrinsic neutron background in the Multi-Grid detector

open access: yes, 2018
One of the key requirements for neutron scattering instruments is the Signal-to-Background ratio (SBR). This is as well a design driving requirement for many instruments at the European Spallation Source (ESS), which aspires to be the brightest neutron ...
Dian, E.   +5 more
core   +1 more source

Mechanistic basis for inhibition of the extended‐spectrum β‐lactamase GES‐1 by enmetazobactam and tazobactam

open access: yesFEBS Letters, EarlyView.
Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer   +10 more
wiley   +1 more source

Modified dispersion relations and the response of the rotating Unruh-DeWitt detector

open access: yes, 2011
We study the response of a rotating monopole detector that is coupled to a massless scalar field which is described by a non-linear dispersion relation in flat spacetime.
A. A. Starobinsky   +11 more
core   +1 more source

C9orf72 ALS‐causing mutations lead to mislocalization and aggregation of nucleoporin Nup107 into stress granules

open access: yesFEBS Letters, EarlyView.
Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient‐derived neurons and C. elegans models, we find that the nucleoporin Nup107 is dysregulated in C9orf72‐associated ALS. Conversely, reducing Nup107 levels mitigates disease‐related changes.
Saygın Bilican   +7 more
wiley   +1 more source

Realistic images generation for training artificial neural networks in robot navigation problem

open access: yesInformatika, 2018
The problem of obtaining training dataset for setting weights of neural network designed for indoor detection of doors is considered and solved on the particular example. A method for generating realistic synthetic data is developed.
L. A. Khodasevich
doaj  

Simulation of avalanche low-gain sensor performance in X-ray detection [PDF]

open access: yesمجله علوم و فنون هسته‌ای
X-ray applications in imaging and beyond require efficient and optimal detectors. Energy separation, time loss, and manufacturing cost are among the features that led us to design a semiconductor detector.
M. Dansi, M.B. Fathi
doaj   +1 more source

Novel and unscrutinized immune entities of the zebrafish gut

open access: yesFEBS Letters, EarlyView.
Understudied cells of the zebrafish immune system include bona fide immune cells and epithelial (‐derived) cells with immune functions. Research focusing on zebrafish cells which demonstrate similarities to mammalian immune cell counterparts may help us understand the pathologies in which they are implicated. Currently available and advanced tools make
Audrey Inge Schytz Andersen‐Civil   +5 more
wiley   +1 more source

Electromagnetic detectors [PDF]

open access: yes, 2005
This paper discusses the design and physics of some electromagnetic detectors. 19 refs., 16 figs. (LSP)
openaire   +2 more sources

From lactation to malignancy: A comparison between healthy and cancerous breast gland at single‐cell resolution reveals new issues for tumorigenesis

open access: yesFEBS Letters, EarlyView.
Single‐cell RNA sequencing reveals an opposite role of SLPI in basal tumors based on metastatic spread, along with shared activation of specific regulons in cancer cells and mature luminal lactocytes, as well as downregulation of MALAT1 and NEAT1 in the latter.
Pietro Ancona   +4 more
wiley   +1 more source

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