Results 51 to 60 of about 116,850 (264)

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Medium and high energy electron detectors onboard BeiDou navigation satellite in MEO

Open Astronomy, 2023
This work introduces the instruments’ design of multi-directional medium-energy electron detector (energy range: 30–770 keV) and high-energy electron detector (energy range: 400 keV to 5.8 MeV) deployed on one of the BeiDou navigation satellites in ...
Zhang Huanxin, Shen Guohong, Zhang Shenyi, Quan Lin, Tian Chao, Cui Xiangtang, Tuo Changsheng, Hou Donghui, Sun Ying, Cheng Lihui, Zhou Ping, Ji Wentao   +11 more
doaj   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

Research on Calibration Method of Relative Detection Efficiency for Large Number of 3He Detector

Yuanzineng kexue jishu, 2022
In the development of some equipments or in the production environment of specific fissionable nuclear materials, neutron flux distribution measurements are required using a large number of neutron detectors to determine the production status.
YU Jialei;HOU Long;WANG Qi;SUN Qi;ZHU Qingfu
doaj  

Calibrating canines—a universal detector calibrant for detection dogs

Frontiers in Allergy
Since the advent of the Universal Detector Calibrant (UDC) by scientists at Florida International University in 2013, this tool has gone largely unrecognized and under-utilized by canine scent detection practitioners. The UDC is a chemical that enables reliability testing of biological and instrumental detectors. Training a biological detector, such as
Michele N. Maughan, Jenna D. Gadberry, Caitlin E. Sharpes, Patricia E. Buckley, Aleksandr E. Miklos, Kenneth G. Furton, Lauryn E. DeGreeff, Lauryn E. DeGreeff, Nathaniel J. Hall, Robin R. Greubel, Katylynn B. Sloan   +10 more
openaire   +3 more sources

Calibration of the GLAST Burst Monitor detectors [PDF]

AIP Conference Proceedings, 2007
2 pages, 1 figure; to appear in the Proc. of the First Int. GLAST Symp. (Stanford, Feb. 5-8, 2007), eds.
Von, KA., Bissaldi, E., Lichti, GG., Steinle, H., Krumrey, M., Gerlach, M., Fishman, GJ., Meegan, C., Bhat, N., Briggs, MS., Diehl, R., Connaughton, V., Greiner, J., Kippen, RM., Kouveliotou, C., Paciesas, W., Preece, R., Wilson-Hodge, C.   +17 more
openaire   +4 more sources

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Sourceless efficiency calibration method for γ spectrum based on numerical analysis

He jishu
BackgroundEfficiency calibration is an important prerequisite for γ-spectroscopy measurement, and its accuracy directly affects the reliability of measurement results.
YE Erlei, SHEN Chunxia, NAN Hongjie, LAI Yongfang   +3 more
doaj   +1 more source