Results 71 to 80 of about 1,072,644 (295)

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer

Molecular Oncology, EarlyView.
New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau, Daniel Pincher, Clifford Young, Nicholas Chappell, Noor A. Lokman, Parul Mittal, Leigh Donnellan, Martin K. Oehler, Doug A. Brooks, Peter Hoffmann   +9 more
wiley   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Medium and high energy electron detectors onboard BeiDou navigation satellite in MEO

Open Astronomy, 2023
This work introduces the instruments’ design of multi-directional medium-energy electron detector (energy range: 30–770 keV) and high-energy electron detector (energy range: 400 keV to 5.8 MeV) deployed on one of the BeiDou navigation satellites in ...
Zhang Huanxin, Shen Guohong, Zhang Shenyi, Quan Lin, Tian Chao, Cui Xiangtang, Tuo Changsheng, Hou Donghui, Sun Ying, Cheng Lihui, Zhou Ping, Ji Wentao   +11 more
doaj   +1 more source

The MINOS calibration detector

Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 2006
This paper describes the MINOS calibration detector (CalDet) and the procedure used to calibrate it. The CalDet, a scaled-down but functionally equivalent model of the MINOS Far and Near detectors, was exposed to test beams in the CERN PS East Area during 2001–2003 to establish the response of the MINOS calorimeters to hadrons, electrons and muons in ...
P. Adamson, G. Crone, L. Jenner, R. Nichol, R. Saakyan, C. Smith, J. Thomas, M. Kordosky, K. Lang, P. Vahle, A. Belias, T. Nicholls, G. Pearce, D. Petyt, M. Barker, A. Cabrera, J. Hartnell, P.S. Miyagawa, N. Tagg, A. Weber, E. Falk Harris, P.G. Harris, R. Morse, P. Symes, D. Michael, P.J. Litchfield, R. Lee, S. Boyd   +27 more
openaire   +2 more sources

Calibration of the GLAST Burst Monitor detectors [PDF]

AIP Conference Proceedings, 2007
2 pages, 1 figure; to appear in the Proc. of the First Int. GLAST Symp. (Stanford, Feb. 5-8, 2007), eds.
Von, KA., Bissaldi, E., Lichti, GG., Steinle, H., Krumrey, M., Gerlach, M., Fishman, GJ., Meegan, C., Bhat, N., Briggs, MS., Diehl, R., Connaughton, V., Greiner, J., Kippen, RM., Kouveliotou, C., Paciesas, W., Preece, R., Wilson-Hodge, C.   +17 more
openaire   +4 more sources

Effect of terahertz irradiation on DNA damage repair in living cells

FEBS Open Bio, EarlyView.
We investigated the effect of terahertz (THz) wave irradiation on DNA double‐strand break (DSB) repair in living cells. We found that THz irradiation enhanced DSB repair at specific frequencies, whereas heat treatment inhibited it, indicating that this effect is nonthermal and frequency‐specific.
Yuya Ueno, Shota Yamazaki, Hiromichi Hoshina, Masahiko Harata   +3 more
wiley   +1 more source

NaI(Tl) Detector Efficiency Computation Using Radioactive Parallelepiped Sources Based on Efficiency Transfer Principle

Science and Technology of Nuclear Installations, 2015
The efficiency transfer (ET) principle is considered as a simple numerical simulation method, which can be used to calculate the full-energy peak efficiency (FEPE) of 3″×3″ NaI(Tl) scintillation detector over a wide energy range.
Mohamed S. Badawi, Mona M. Gouda, Ahmed M. El-Khatib, Abouzeid A. Thabet, Ahmed A. Salim, Mahmoud I. Abbas   +5 more
doaj   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Wide Dynamic Range, High Uniformity Spectral Irradiance Source for Calibration of Scientific-Grade, Large-Size Space Detectors

Remote Sensing
In order to meet the high uniformity calibration requirements for scientific-grade, large-size space detectors used in the CHES Extrasolar Planet Exploration Mission, this paper presents the design of a wide dynamic range, high uniformity spectral ...
Deyao Kong, Yinlin Yuan, Haitao Li, Wenchao Zhai, Xiaobing Zheng   +4 more
doaj   +1 more source