Results 91 to 100 of about 1,072,644 (295)

A Practical Framework for Event-Level Evaluation and Verifiable Counterfactual Explanation in Multivariate Time-Series Anomaly Detection

open access: yesApplied Sciences
Multivariate time-series anomaly detection is often evaluated with point-adjusted metrics, which can overstate practical performance when alarms are judged at the event level.
Bo Zhong   +3 more
doaj   +1 more source

Structural and biochemical insights into the thermostable esterase Ta0887 from Thermoplasma acidophilum

open access: yesFEBS Open Bio, EarlyView.
In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey   +4 more
wiley   +1 more source

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

open access: yesFEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

Using fluorescence fluctuation spectroscopy to quantify molecular dynamics within cells

open access: yesFEBS Open Bio, EarlyView.
Microscopy techniques like fluorescence correlation spectroscopy (FCS) and number and brightness analysis (N&B) allow to quantify concentrations, diffusion rates, and oligomerization of fluorescently labeled molecules in the living cell. In this protocol the principles of how to set up these types of experiments are described including calibration ...
Mark A. Hink
wiley   +1 more source

Sourceless efficiency calibration method for γ spectrum based on numerical analysis

open access: yesHe jishu
BackgroundEfficiency calibration is an important prerequisite for γ-spectroscopy measurement, and its accuracy directly affects the reliability of measurement results.
YE Erlei   +3 more
doaj   +1 more source

Calibration of the IMB detector

open access: yesNuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 1995
The IMB detector (named after its founding institutions: University of California, Irvine, the University of Michigan and Brookhaven National Laboratory) collected data on a wide range of phenomena for over eight years. It was the first and the largest of the ring imaging water Cherenkov detectors.
R. Becker-Szendy   +38 more
openaire   +1 more source

Characterization of the key membrane protein cytochrome Cyc2 from Ghiorsea bivora

open access: yesFEBS Open Bio, EarlyView.
This study reports the first detailed biochemical analysis of Cyc2TAG1_1, a cytochrome protein involved in microbial iron oxidation. We produced and purified this enzyme in E. coli, then measured its iron‐oxidizing efficiency, and characterized its electrical and structural properties.
Josiane Azizi   +6 more
wiley   +1 more source

Jet energy resolution in proton-proton collisions at s√=7 TeV recorded in 2010 with the ATLAS detector [PDF]

open access: yes, 2013
The measurement of the jet energy resolution is presented using data recorded with the ATLAS detector in proton-proton collisions at s√=7 TeV . The sample corresponds to an integrated luminosity of 35 pb−1.

core   +2 more sources

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