Results 91 to 100 of about 945,412 (297)

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Expected resolution limits of x-ray free-electron laser single-particle imaging for realistic source and detector properties. [PDF]

Struct Dyn, 2022
E J, Kim Y, Bielecki J, Sikorski M, de Wijn R, Fortmann-Grote C, Sztuk-Dambietz J, Koliyadu JCP, Letrun R, Kirkwood HJ, Sato T, Bean R, Mancuso AP, Kim C.   +13 more
europepmc   +1 more source

The Micro Slit Gas Detector

, 1999
We describe the first tests with a new proportional gas detector. Its geometry consists in slits opened in a copper metallized kapton foil with 30 micron anode strips suspended in these openings.
Gomez, F., Labbe, J. Claude, Nunez, T., Pazos, A., Vazquez, P.   +4 more
core   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Flavor and energy inference for the high-energy IceCube neutrinos

, 2017
We present a flavor and energy inference analysis for each high-energy neutrino event observed by the IceCube observatory during six years of data taking.
D'Amico, Giacomo
core   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Liquid-nitrogen cooled, free-running single-photon sensitive detector at telecommunication wavelengths

, 2015
The measurement of light characteristics at the single- and few photon level plays a key role in many quantum optics applications. Often photodetection is preceded with the transmission of quantum light over long distances in optical fibers with their ...
Covi, M., Günthner, T., Krapick, S., Laiho, K., Pressl, B., Silberhorn, C., Weihs, G.   +6 more
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

The model of an anomaly detector for HiLumi LHC magnets based on Recurrent Neural Networks and adaptive quantization

, 2017
This paper focuses on an examination of an applicability of Recurrent Neural Network models for detecting anomalous behavior of the CERN superconducting magnets. In order to conduct the experiments, the authors designed and implemented an adaptive signal
De Matteis, Ernesto, Mertik, Matej, Skoczeń, Andrzej, Wielgosz, Maciej   +3 more
core   +1 more source

Properties of the CsI(Tl) detector elements of the CALIFA detector

Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 2019
Nuclear instruments & methods in physics research / A 940, 393 - 404 (2019).
Knyazev, A., Park, J., Golubev, P., Cederkäll, J., Álvarez Pol, Héctor, Cabanelas, P., Casarejos Ruiz, Enrique, Causeret, L., Cortina Gil, D., Díaz Fernández, P., Feijoo, M., Galaviz, D., Galiana, E., Gernhäuser, R., Hartig, A. L., Heinz, A., Heiss, B., Ignatov, A., Johansson, H., Klenze, P., Kröll, T., Nilsson, T., Perea, A., Rhee, H.-B., Tengblad, O., Teubig, P.   +25 more
openaire   +5 more sources