Results 31 to 40 of about 553,105 (269)

The human gut microbiome across the life course

open access: yesFEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero   +4 more
wiley   +1 more source

Blinded assessment of treatment effects utilizing information about the randomization block length [PDF]

open access: yes, 2009
It is essential for the integrity of double-blind clinical trials that during the study course the individual treatment allocations of the patients as well as the treatment effect remain unknown to any involved person.
Miller, F. (Frank)   +2 more
core   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

open access: yesFEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace   +6 more
wiley   +1 more source

A Randomized Subspace Learning Based Anomaly Detector for Hyperspectral Imagery [PDF]

open access: yesRemote Sensing, 2018
This paper proposes a randomized subspace learning based anomaly detector (RSLAD) for hyperspectral imagery (HSI). Improved from robust principal component analysis, the RSLAD assumes that the background matrix is low-rank, and the anomaly matrix is sparse with a small portion of nonzero columns (i.e., column-wise). It also assumes the anomalies do not
Weiwei Sun 0005   +4 more
openaire   +3 more sources

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

open access: yesFEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa   +2 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Enhanced security for multi-detector quantum random number generators [PDF]

open access: yesQuantum Science and Technology, 2016
Quantum random number generators (QRNG) represent an advanced solution for randomness generation, essential in every cryptographic applications. In this context, integrated arrays of single photon detectors have promising applications as QRNGs based on the spatial detection of photons.
MARANGON, DAVIDE GIACOMO   +3 more
openaire   +3 more sources

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

open access: yesFEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt   +8 more
wiley   +1 more source

The BaBar detector [PDF]

open access: yes, 2001
This is the pre-print version of the Article. The official published version can be accessed from the link below. Copyright @ 2002 Elsevier.BABAR, the detector for the SLAC PEP-II asymmetric e+e− B Factory operating at the (4S) resonance, was designed ...
Fouque G   +999 more
core   +1 more source

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