A functionally divergent intrinsically disordered region underlying the conservation of stochastic signaling. [PDF]
PLoS Genetics, 2021 Stochastic signaling dynamics expand living cells' information processing capabilities. An increasing number of studies report that regulators encode information in their pulsatile dynamics.
Ian S Hsu +5 more
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A minimal model of signaling network elucidates cell-to-cell stochastic variability in apoptosis. [PDF]
PLoS ONE, 2010 BACKGROUND: Signaling networks are designed to sense an environmental stimulus and adapt to it. We propose and study a minimal model of signaling network that can sense and respond to external stimuli of varying strength in an adaptive manner.
Subhadip Raychaudhuri
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Data-based stochastic modeling reveals sources of activity bursts in single-cell TGF-β signaling.
PLoS Computational Biology, 2022 Cells sense their surrounding by employing intracellular signaling pathways that transmit hormonal signals from the cell membrane to the nucleus. TGF-β/SMAD signaling encodes various cell fates, controls tissue homeostasis and is deregulated in diseases ...
Niklas Kolbe +5 more
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Identifying Desirable Function Perturbations in Signaling Pathways Through Stochastic Analysis
IEEE Access, 2020 The logical representation and analyses of biological systems provide us with valuable insights. Inherent fluctuations play an important role in the long-term behaviors of biological systems.
Jun Hu +4 more
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Entropy, 2022 Stochastic resonance in clusters of major histocompatibility molecules is extended by a more detailed description of adaptive thresholding and by applying the notion of suprathreshold stochastic resonance as a stochastically quantizing encoder of ...
László Bene +2 more
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BMC Bioinformatics, 2022 Background In cell signaling pathways, proteins interact with each other to determine cell fate in response to either cell-extrinsic (micro-environmental) or intrinsic cues.
Minsoo Kim, Eunjung Kim
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Stochastic responses may allow genetically diverse cell populations to optimize performance with simpler signaling networks. [PDF]
PLoS ONE, 2013 Two theories have emerged for the role that stochasticity plays in biological responses: first, that it degrades biological responses, so the performance of biological signaling machinery could be improved by increasing molecular copy numbers of key ...
Christopher C Govern, Arup K Chakraborty
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Coupled stochastic spatial and non-spatial simulations of ErbB1 signaling pathways demonstrate the importance of spatial organization in signal transduction. [PDF]
PLoS ONE, 2009 BACKGROUND: The ErbB family of receptors activates intracellular signaling pathways that control cellular proliferation, growth, differentiation and apoptosis.
Michelle N Costa +4 more
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Stochastic delay accelerates signaling in gene networks. [PDF]
PLoS Computational Biology, 2011 The creation of protein from DNA is a dynamic process consisting of numerous reactions, such as transcription, translation and protein folding. Each of these reactions is further comprised of hundreds or thousands of sub-steps that must be completed ...
Krešimir Josić +4 more
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Stochastic dynamics of Type-I interferon responses.
PLoS Computational Biology, 2022 Interferon (IFN) activates the transcription of several hundred of IFN stimulated genes (ISGs) that constitute a highly effective antiviral defense program.
Benjamin D Maier +8 more
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