Stochastic responses may allow genetically diverse cell populations to optimize performance with simpler signaling networks. [PDF]
PLoS ONE, 2013 Two theories have emerged for the role that stochasticity plays in biological responses: first, that it degrades biological responses, so the performance of biological signaling machinery could be improved by increasing molecular copy numbers of key ...
Christopher C Govern, Arup K Chakraborty
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Data-based stochastic modeling reveals sources of activity bursts in single-cell TGF-β signaling.
PLoS Computational Biology, 2022 Cells sense their surrounding by employing intracellular signaling pathways that transmit hormonal signals from the cell membrane to the nucleus. TGF-β/SMAD signaling encodes various cell fates, controls tissue homeostasis and is deregulated in diseases ...
Niklas Kolbe +5 more
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Coupled stochastic spatial and non-spatial simulations of ErbB1 signaling pathways demonstrate the importance of spatial organization in signal transduction. [PDF]
PLoS ONE, 2009 BACKGROUND: The ErbB family of receptors activates intracellular signaling pathways that control cellular proliferation, growth, differentiation and apoptosis.
Michelle N Costa +4 more
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Stochastic dynamics of Type-I interferon responses.
PLoS Computational Biology, 2022 Interferon (IFN) activates the transcription of several hundred of IFN stimulated genes (ISGs) that constitute a highly effective antiviral defense program.
Benjamin D Maier +8 more
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Bistability versus bimodal distributions in gene regulatory processes from population balance. [PDF]
PLoS Computational Biology, 2011 In recent times, stochastic treatments of gene regulatory processes have appeared in the literature in which a cell exposed to a signaling molecule in its environment triggers the synthesis of a specific protein through a network of intracellular ...
Che-Chi Shu +4 more
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Dynamic signaling with stochastic stakes
Theoretical Economics, 2020 We study dynamic signaling in a game of stochastic stakes. Each period, a privately informed agent of binary type chooses whether to continue receiving a return that is an increasing function of both her reputation and an exogenous public stakes variable or to irreversibly exit the game. A strong type has a dominant strategy to continue.
Gryglewicz, Sebastian, Kolb, Aaron
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Quantum sensing of intermittent stochastic signals [PDF]
Physical Review A, 2021 5 pages, 4 ...
Sara L. Mouradian +4 more
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G3: Genes, Genomes, Genetics, 2019 Several examples of transcription factors that show stochastic, unsynchronized pulses of nuclear localization have been described. Here we show that under constant calcium stress, nuclear localization pulses of the transcription factor Crz1 follow ...
Ian S. Hsu +3 more
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Noise propagation in two-step series MAPK cascade. [PDF]
PLoS ONE, 2012 Series MAPK enzymatic cascades, ubiquitously found in signaling networks, act as signal amplifiers and play a key role in processing information during signal transduction in cells.
Venkata Dhananjaneyulu +3 more
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Asymmetric stochastic switching driven by intrinsic molecular noise. [PDF]
PLoS ONE, 2012 Low-copy-number molecules are involved in many functions in cells. The intrinsic fluctuations of these numbers can enable stochastic switching between multiple steady states, inducing phenotypic variability.
David Frigola +3 more
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