Results 31 to 40 of about 53,222 (261)
Membranes, 2021 Calcium (Ca2+) plays a central role in the excitation and contraction of cardiac myocytes. Experiments have indicated that calcium release is stochastic and regulated locally suggesting the possibility of spatially heterogeneous calcium levels in the ...
Tuan Minh Hoang-Trong +3 more
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PLoS Computational Biology, 2021 Biochemical systems consist of numerous elementary reactions governed by the law of mass action. However, experimentally characterizing all the elementary reactions is nearly impossible.
Yun Min Song +2 more
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Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Controlling precise movement with stochastic signals [PDF]
Biological Cybernetics, 2010 In a noisy system, such as the nervous system, can movements be precisely controlled as experimentally demonstrated? We point out that the existing theory of motor control fails to provide viable solutions. However, by adopting a generalized approach to the nonconvex optimization problem with the Young measure theory, we show that a precise movement ...
Enrico Rossoni, Jing Kang, Jianfeng Feng
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FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
Experimental Design for Stochastic Models of Nonlinear Signaling Pathways Using an Interval-Wise Linear Noise Approximation and State Estimation. [PDF]
PLoS ONE, 2016 BACKGROUND:Computational modeling is a key technique for analyzing models in systems biology. There are well established methods for the estimation of the kinetic parameters in models of ordinary differential equations (ODE).
Christoph Zimmer
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FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source
Emergence of noise-induced oscillations in the central circadian pacemaker.
PLoS Biology, 2010 Bmal1 is an essential transcriptional activator within the mammalian circadian clock. We report here that the suprachiasmatic nucleus (SCN) of Bmal1-null mutant mice, unexpectedly, generates stochastic oscillations with periods that overlap the circadian
Caroline H Ko +9 more
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Unraveling the design principle for motif organization in signaling networks. [PDF]
PLoS ONE, 2011 Cellular signaling networks display complex architecture. Defining the design principle of this architecture is crucial for our understanding of various biological processes.
Samrat Chatterjee, Dhiraj Kumar
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Early warning signals of stochastic switching [PDF]
Proceedings of the Royal Society B: Biological Sciences, 2013 The development of statistical signals for anticipating changes of state (‘regime shifts’) is an active area of research in ecology [[1][1],[2][2]], earth and atmospheric science [[3][3]], and biology [[4][4],[5][5]]. Causes of regime shifts include noise-induced transitions [[6][6]],
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