Results 21 to 30 of about 1,446,606 (252)
Elucidating the sources of β-catenin dynamics in human neural progenitor cells. [PDF]
PLoS ONE, 2012 Human neural progenitor cells (hNPCs) form a new prospect for replacement therapies in the context of neurodegenerative diseases. The Wnt/β-catenin signaling pathway is known to be involved in the differentiation process of hNPCs. RVM cells form a common
Orianne Mazemondet +4 more
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Performance of Modal Signaling vs. medium dielectric variability [PDF]
, 2012 This paper addresses the feasibility of the so-called Modal Signaling (MS) transmission scheme from a stochastic viewpoint. MS has been proposed for crosstalk mitigation over interconnects and is based on the encoding of signals onto fundamental ...
Stievano, Igor Simone +5 more
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eLife, 2017 We present in vivo single-cell FRET measurements in the Escherichia coli chemotaxis system that reveal pervasive signaling variability, both across cells in isogenic populations and within individual cells over time.
Johannes M Keegstra +5 more
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A posteriori error estimation for stochastic static problems [PDF]
, 2014 To solve stochastic static field problems, a discretization by the Finite Element Method can be used. A system of equations is obtained with the unknowns (scalar potential at nodes for example) being random variables. To solve this stochastic system, the
MAC, Hung, CLENET, Stephane
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Multiple signaling pathways coordinate to induce a threshold response in a chordate embryo. [PDF]
PLoS Genetics, 2013 In animal development, secreted signaling molecules evoke all-or-none threshold responses of target gene transcription to specify cell fates. In the chordate Ciona intestinalis, the neural markers Otx and Nodal are induced at early embryonic stages by ...
Naoyuki Ohta, Yutaka Satou
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Patterning the insect eye: From stochastic to deterministic mechanisms.
PLoS Computational Biology, 2018 While most processes in biology are highly deterministic, stochastic mechanisms are sometimes used to increase cellular diversity. In human and Drosophila eyes, photoreceptors sensitive to different wavelengths of light are distributed in stochastic ...
Haleh Ebadi +6 more
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The fidelity of dynamic signaling by noisy biomolecular networks [PDF]
, 2013 Cells live in changing, dynamic environments. To understand cellular decision-making, we must therefore understand how fluctuating inputs are processed by noisy biomolecular networks.
Voliotis Margaritis +18 more
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Computational Modeling for the Activation Cycle of G-proteins by G-protein-coupled Receptors [PDF]
Electronic Proceedings in Theoretical Computer Science, 2010 In this paper, we survey five different computational modeling methods. For comparison, we use the activation cycle of G-proteins that regulate cellular signaling events downstream of G-protein-coupled receptors (GPCRs) as a driving example.
Yifei Bao +3 more
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Efficient simulation of stochastic chemical kinetics with the Stochastic Bulirsch-Stoer extrapolation method [PDF]
, 2014 BackgroundBiochemical systems with relatively low numbers of components must be simulated stochastically in order to capture their inherent noise. Although there has recently been considerable work on discrete stochastic solvers, there is still a need ...
Barrio Solórzano, Manuel +11 more
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Membranes, 2021 Calcium (Ca2+) plays a central role in the excitation and contraction of cardiac myocytes. Experiments have indicated that calcium release is stochastic and regulated locally suggesting the possibility of spatially heterogeneous calcium levels in the ...
Tuan Minh Hoang-Trong +3 more
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