Results 41 to 50 of about 53,222 (261)
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Optimal Trading with Signals and Stochastic Price Impact
SIAM Journal on Financial Mathematics, 2022 Trading frictions are stochastic. They are, moreover, in many instances fast-mean reverting. Here, we study how to optimally trade in a market with stochastic price impact and study approximations to the resulting optimal control problem using singular perturbation methods. We prove, by constructing sub- and super-solutions, that the approximations are
Jean-Pierre Fouque +2 more
openaire +3 more sources
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Modeling craniofacial development reveals spatiotemporal constraints on robust patterning of the mandibular arch. [PDF]
PLoS Computational Biology, 2018 How does pattern formation occur accurately when confronted with tissue growth and stochastic fluctuations (noise) in gene expression? Dorso-ventral (D-V) patterning of the mandibular arch specifies upper versus lower jaw skeletal elements through a ...
Lina Meinecke +5 more
doaj +1 more source
Is the stochastic signal really detectable?
Physical Review DSeparating a stochastic gravitational wave background (SGWB) from noise is a challenging statistical task. One approach to establishing a detection criterion for the SGWB is using Bayesian evidence. If the evidence ratio (Bayes factor) between models with and without the signal exceeds a certain threshold, the signal is considered detected.
Federico Pozzoli +3 more
openaire +3 more sources
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Stochastic gene expression in auxin signaling in the floral meristem of Arabidopsis thaliana
Nature CommunicationsCells display striking stochasticity in gene expression, which plays an important role in development, disease, and regeneration. Previous studies have found stochastic gene expression in bacteria, yeast, and from constitutive promoters in Arabidopsis ...
Shuyao Kong +3 more
doaj +1 more source
Stochastic Resonant Signaling in Enzyme Cascades
Physical Review Letters, 2007 We observe the phenomenon of stochastic resonant signaling in signal amplification enzyme cascades, where certain optimal reaction rates minimize the average threshold-crossing time. We develop a new analytical technique to obtain the mean first passage time, based on a novel decomposition of the master equation.
Yueheng, Lan, Garegin A, Papoian
openaire +3 more sources
Discerning protein pools by selective staining with self‐labeling tags
FEBS Letters, EarlyView.Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source
Maximally nonlocal Clauser-Horne-Shimony-Holt scenarios
Scientific Reports, 2018 The key feature in correlations established by multi-party quantum entangled states is nonlocality. A quantity to measure the average nonlocality, distinguishing it from shared randomness and in a direct relation with no-signaling stochastic processes ...
Jesús Urías +1 more
doaj +1 more source