Results 51 to 60 of about 53,222 (261)
Cells, 2013 Apoptotic cell death is coordinated through two distinct (type 1 and type 2) intracellular signaling pathways. How the type 1/type 2 choice is made remains a central problem in the biology of apoptosis and has implications for apoptosis related diseases ...
Somkanya C Raychaudhuri +1 more
doaj +1 more source
A density-dependent switch drives stochastic clustering and polarization of signaling molecules. [PDF]
PLoS Computational Biology, 2011 Positive feedback plays a key role in the ability of signaling molecules to form highly localized clusters in the membrane or cytosol of cells.
Alexandra Jilkine +3 more
doaj +1 more source
Cytosolic Self-DNA—A Potential Source of Chronic Inflammation in Aging
Cells, 2021 Aging is the consequence of a lifelong accumulation of stochastic damage to tissues and cellular components. Advancing age closely associates with elevated markers of innate immunity and low-grade chronic inflammation, probably reflecting steady ...
Mansour Akbari +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Generic Weighted Filtering of Stochastic Signals
IEEE Transactions on Signal Processing, 2009 In this paper, a new theory of optimal weighted nonlinear filtering is presented. Two filter models are considered. The first model is based on a representation of the filter in the polynomial-like form with q terms where each term consists of weighted matrices and the matrix determined from the error minimization problem.
Anatoli Torokhti, Jonathan H. Manton
openaire +2 more sources
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Molecular Oncology, EarlyView.The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant +7 more
wiley +1 more source
BMC Genomics, 2012 The Steady State (SS) probability distribution is an important quantity needed to characterize the steady state behavior of many stochastic biochemical networks.
Karim Shahriar +2 more
doaj +1 more source
Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance
Aging and Cancer, EarlyView.NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang +3 more
wiley +1 more source
Microdomain calcium fluctuations as a colored noise process
Frontiers in Genetics, 2014 Calcium ions play a key role in subcellular signaling as localized transients of the intracellular calcium concentration modify the activity of ion channels, enzymes and transcription factors, among others.
Frederic evon Wegner +3 more
doaj +1 more source