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The Silver Jubilee (2025) of Insulin Glargine: Introducing the Era of Long-Acting Insulin Analogues for Diabetes Mellitus. [PDF]

Diabetes Obes Metab
ABSTRACT In the year 2000 the first once daily long‐acting bioengineered insulin analogue (LAIA), insulin glargine (‘glargine’), a true basal insulin (BI), became available for clinical use. This led to the decline in the 50‐year‐old era and prominence of the intermediate‐acting insulins, neutral protamine Hagedorn (NPH) and lente, requiring twice ...
Bolli GB, Home PD, Lepore M, Riddle MC, Porcellati F, Fanelli CG, Lucidi P, Yki-Järvinen H, Becker RH, Owens DR.   +9 more
europepmc   +2 more sources

Effects of exogenous detemir and glargine insulin on the detection of endogenous C-peptide and endogenous insulin [PDF]

European Journal of Medical Research
Aims To examine the effects of administering detemir and glargine insulin on the detection of endogenous C-peptide and insulin levels. Methods This study enrolled 69 patients with type 2 diabetes (T2DM) who use long-acting insulin therapy.
Yi-ting Wang, Yi-fang Ma, Yao Zheng, Yang Ou, Yi-kun Zhou   +4 more
doaj   +2 more sources

Engineering a Glucose-Responsive Glucagon Prodrug Through Arginine-Phenylboronic Acid Pendant Modification. [PDF]

Small Sci
A single‐molecule glucagon prodrug enables self‐regulated delivery through glucose‐dependent charge modulation. Phenylboronic acid–glucose binding induces aggregation and subcutaneous depot formation at normoglycemia, while glucose depletion restores solubility and triggers glucagon release, providing on‐demand protection against hypoglycemia ...
DeWolf EL, Chen W, Webber B, Power EM, Kilmer R, Kadu P, Xian S, Webber MJ.   +7 more
europepmc   +2 more sources

Sustained Treatment with Insulin Detemir in Mice Alters Brain Activity and Locomotion. [PDF]

PLoS ONE, 2016
AIMS:Recent studies have identified unique brain effects of insulin detemir (Levemir®). Due to its pharmacologic properties, insulin detemir may reach higher concentrations in the brain than regular insulin.
Tina Sartorius, Anita M Hennige, Andreas Fritsche, Hans-Ulrich Häring   +3 more
doaj   +1 more source

Comparative Study of High-Resolution LysB29(Nε-myristoyl) des(B30) Insulin Structures Display Novel Dynamic Causal Interrelations in Monomeric-Dimeric Motions

Crystals, 2023
The treatment of insulin-dependent diabetes mellitus is characterized by artificial supplementation of pancreatic β-cell ability to regulate sugar levels in the blood.
Esra Ayan, Ebru Destan, Abdullah Kepceoglu, Halil Ibrahim Ciftci, Ahmet Kati, Hasan DeMirci   +5 more
doaj   +1 more source

Effects of insulin detemir and NPH insulin on body weight and appetite-regulating brain regions in human type 1 diabetes: a randomized controlled trial. [PDF]

PLoS ONE, 2014
Studies in rodents have demonstrated that insulin in the central nervous system induces satiety. In humans, these effects are less well established.
Larissa W van Golen, Dick J Veltman, Richard G IJzerman, Jan Berend Deijen, Annemieke C Heijboer, Frederik Barkhof, Madeleine L Drent, Michaela Diamant   +7 more
doaj   +1 more source

Comparative study of the usefulness of a novel insulin therapy in Japanese patients with Type 2 diabetes for concomitant use of an oral antidiabetic agent with twice-daily dosing either of insulin aspart, biphasic insulin aspart-30, or insulin detemir: Two times Insulin injection Combined with oral therapy Efficacy Study (TWICE study)

Fujita Medical Journal, 2021
Objectives: It is common to treat type 2 diabetes by regular injections of insulin. We compared the efficacy and safety of twice-daily administration of short-acting, premixed, and long-acting insulins.
Mitsuyasu Itoh, Atsushi Suzuki, Taiya Katoh, Yoshikuni Sawai, Shogo Asano, Shigeo Imamura, Yoshinari Hayashi, Shinobu Goto, Nobuo Takahashi, Tetsuya Kawabe   +9 more
doaj   +1 more source

Flexibility in insulin prescription

Indian Journal of Endocrinology and Metabolism, 2016
This communication explores the concept of flexibility, a propos insulin preparations and insulin regimes used in the management of type 2 diabetes.
Sanjay Kalra, Yashdeep Gupta, Ambika Gopalakrishnan Unnikrishnan   +2 more
doaj   +1 more source

Treatment of Type 1 and Type 2 Diabetes Mellitus with Insulin Detemir, a Long-Acting Insulin Analog

Clinical Medicine Insights: Endocrinology and Diabetes, 2010
Insulin detemir is a long-acting basal insulin approved for use in patients with type 1 (T1DM) or type 2 diabetes (T2DM). Insulin detemir has demonstrated equivalent glycemic control and hypoglycemic risk when compared to insulin glargine, and insulin ...
Jason R. Young, Carrie Mcadam-Marx
doaj   +1 more source

Forum for Injection Technique (FIT), India: The Indian recommendations 2.0, for best practice in Insulin Injection Technique, 2015

Indian Journal of Endocrinology and Metabolism, 2015
As injectable therapies such as human insulin, insulin analogs, and glucagon-like peptide-1 receptor agonists are used to manage diabetes, correct injection technique is vital for the achievement of glycemic control.
Nikhil Tandon, Sanjay Kalra, Yatan Pal Singh Balhara, Manash P Baruah, Manoj Chadha, Hemraj B Chandalia, Subhankar Chowdhury, Kesavadev Jothydev, Prasanna K. M. Kumar, Madhu S V, Ambrish Mithal, Sonal Modi, Shailesh Pitale, Rakesh Sahay, Rishi Shukla, Annamalai Sundaram, Ambika G Unnikrishnan, Subhash K Wangnoo   +17 more
doaj   +1 more source