Results 101 to 110 of about 1,997,664 (317)

Mechanistic basis for inhibition of the extended‐spectrum β‐lactamase GES‐1 by enmetazobactam and tazobactam

open access: yesFEBS Letters, EarlyView.
Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer   +10 more
wiley   +1 more source

Generalizing the Cross Product to N Dimensions: A Novel Approach for Multidimensional Analysis and Applications

open access: yesMathematics
This paper presents a generalization of the cross product to N dimensions, extending the classical operation beyond its traditional confines in three-dimensional space.
Samir Brahim Belhaouari   +6 more
doaj   +1 more source

Multiple gcd-closed sets and determinants of matrices associated with arithmetic functions

open access: yesOpen Mathematics, 2016
Let f be an arithmetic function and S= {x1, …, xn} be a set of n distinct positive integers. By (f(xi, xj)) (resp. (f[xi, xj])) we denote the n × n matrix having f evaluated at the greatest common divisor (xi, xj) (resp. the least common multiple [xi, xj]
Hong Siao, Hu Shuangnian, Hong Shaofang
doaj   +1 more source

C9orf72 ALS‐causing mutations lead to mislocalization and aggregation of nucleoporin Nup107 into stress granules

open access: yesFEBS Letters, EarlyView.
Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient‐derived neurons and C. elegans models, we find that the nucleoporin Nup107 is dysregulated in C9orf72‐associated ALS. Conversely, reducing Nup107 levels mitigates disease‐related changes.
Saygın Bilican   +7 more
wiley   +1 more source

On Factorization and Calculation of Determinant of Block Matrices with Triangular Submatrices

open access: yesJournal of New Theory
In this paper, we consider some block matrices of dimension $nm\times{nm}$ whose components are triangular matrices of dimension $n\times{n}$. We prove that the determinant of such block matrices is determined only by the diagonal elements of their ...
Fatma Altun, Ufuk Kaya
doaj   +1 more source

Determinants and Inverses of Ppoeplitz and Ppankel matrices

open access: yesSpecial Matrices, 2018
In this paper, we consider two kinds of special matrices, which are called Ppoeplitz matrix and Ppankel matrix. The idea of matrix transformation is used to compute the determinants and inverses of the Ppoeplitz matrix and the Ppankel matrix.
Zuo Baishuai, Jiang Zhaolin, Fu Deqian
doaj   +1 more source

THE EMOTIONAL WELL-BEING OF LEARNERS AS A DETERMINANT OF THE TRAINING ACTIVITY [PDF]

open access: yesAnalele Universităţii din Craiova. Psihologie, Pedagogie
Our article focuses on the complex issue of creating the emotional well-being needed by the students in academic learning. Especially after the COVID-19 pandemic, this challenge has become an aspect that is better acknowledged by both the trainers and
Ecaterina Sarah FRĂSINEANU, Vali ILIE
doaj   +1 more source

On Smith's determinant

open access: yesLinear Algebra and its Applications, 1997
The authors give a brief review of papers relating to Smith's determinant [cf. \textit{H. J. S. Smith}, Proc. Lond. Math. Soc. 7, 208--212 (1876; JFM 08.0074.02)] and point out a common structure that can be found in many extensions and analogues of Smith's determinant. The common structure is presented in the language of posets.
Pentti Haukkanen   +2 more
openaire   +2 more sources

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