Results 91 to 100 of about 1,835,027 (350)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
, 2023 We survey determinantal singularities, their deformations, and their topology. This class of singularities generalizes the well studied case of complete intersections in several different aspects, but exhibits a plethora of new phenomena such as for instance non-isolated singularities which are finitely determined, or smoothings with low connectivity ...
Frühbis-Krüger, Anne, Zach, Matthias
openaire +2 more sources
Determinantes da insegurança alimentar no brasil: análise dos dados da PNAD de 2004
, 2015 Sao analisados os dados da pesquisa suplementar sobre seguranca alimentar, feita pelo IBGE, junto com a Pesquisa Nacional por Amostra de Domicilios - PNAD de 2004, utilizando a Escala Brasileira de Inseguranca Alimentar, que classifica os domicilios em ...
Rodolfo Hoffmann
semanticscholar +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Innovaciones organizativas y sus determinantes: Un estudio de casos comparativo
Tecnología en Marcha, 2017 La presente investigación es de tipo cualitativo; estábasada en la técnica de estudio de casos. Se consultó la teoría fundamentada con el objetivo de analizar los factores determinantes de las innovaciones organizativas en empresas del sector de ...
Marjorie Sojo-Castro +1 more
doaj +1 more source
Desnutrición en Bolivia: la geografía y la cultura sí importan [PDF]
(Disponible en idioma inglés únicamente) La frecuencia de problemas de salud y de desnutrición en Bolivia es alarmantemente elevada, incluso comparada con la de otros países en desarrollo.
Alvaro Calzadilla +2 more
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La satisfacción del turista y los aspectos a considerar en la propuesta de un modelo para su medición en destinos de turismo urbano [PDF]
, 2013 La necesidad de los destinos turísticos por obtener ventajas competitivas los obliga a entender mejor que nunca el fenómeno de la satisfacción de sus visitantes.
Olague de la Cruz, José Trinidad +1 more
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Fatores Determinantes do Pagamento de Dividendos no Brasil
, 2015 Este estudo busca identificar os fatores que determinam a politica de distribuicao de proventos das empresas brasileiras de capital aberto listadas na BM&FBOVESPA, no periodo de 1995 a 2011.
C. A. Forti +2 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Hazardous waste shipping in the northern border of Mexico: The situation of Baja California
Estudios Fronterizos, 2013 In this document we evaluate the determinants of shipments of hazardous waste to the US. We consider a sample of firms operating in the state of Baja California for the 2008–2010 sample period.
Ramón A. Castillo Ponce +2 more
doaj