Results 101 to 110 of about 171,305 (308)

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

¿Por qué quiebran los hoteles españoles?: un estudio de sus determinantes

Tourism & Management Studies, 2015
Este trabajo estudia los determinantes de la quiebra en el sector de la pequeña y mediana empresa hotelera española en el período 2000-2007. En concreto, se evalúa una muestra formada por 1,679 hoteles y se utilizan modelos de probabilidad condicional
Milagros Vivel-Búa, Rubén Lado-Sestayo, Luis Otero-González Universidad de Santiago de Compostela, Facultad de Ciencias Económicas   +2 more
doaj   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

FEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira   +2 more
wiley   +1 more source

Qualidade de vida no trabalho de funcionários públicos: papel da nutrição e da qualidade de vida

Acta Scientiarum. Health Sciences, 2011
Qualidade de Vida no Trabalho (QVT) tem sido objeto de preocupação entre profissionais de diferentes áreas. No setor público fala-se pouco em Gestão de QVT, porém percebe-se que o tema vem ganhando espaço.
Milena Nespeca, Denise Cavallini Cyrillo
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Determinantes da Rotatividade das Carteiras dos Fundos de Investimento em Ações

BBR: Brazilian Business Review, 2015
A gestão ativa de um fundo de investimento em ações visa a obter um desempenho superior ao retorno de uma carteira de mercado por meio da rotatividade da carteira do fundo. Este trabalho procura evidenciar, no mercado brasileiro,
Pedro Luiz Albertin Bono Milan, William Eid Junior   +1 more
doaj  

Uso de los blogs políticos: análisis de algunos factores determinantes

Arbor: Ciencia, Pensamiento y Cultura, 2012
Objetivo de este trabajo es avanzar en la comprensión de los determinantes que hacen que un internauta escriba comentarios en un blog político. Más en concreto, se ha decidido averiguar qué variables políticas influyen sobre este comportamiento y qué ...
Stefano De Marco, José Manuel Robles Morales   +1 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Relação entre corrupção e investimento direto externo e investimento de portfólio externo: o caso dos países emergentes [PDF]

, 2011
TCC (graduação) - Universidade Federal de Santa Catarina. Centro Sócio-Econômico. Economia.Este trabalho apresenta o Corruption Perceptions Index como um dos determinantes ao Investimento Direto Externo (IDE) e ao Investimento de Portfólio Externo (IPE).
Sampaio, Luiza Pires de Oliveira
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