Results 191 to 200 of about 1,027,177 (297)

Determinants of angle kappa in cataract patients. [PDF]

Front Med (Lausanne)
Jin L, Hao X, Liu B, Geng W, Ma R, Niu Y, Cao D, Hu Y.   +7 more
europepmc   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Behavioural Determinants of Appropriate Antibiotic Prescribing for Urinary Tract Infections in Nursing Homes: A Qualitative Study of Stakeholders' Perspectives. [PDF]

Antibiotics (Basel)
Coenen I, Lenie S, Coteur K, Hughes C, Foulon V.   +4 more
europepmc   +1 more source

Determinants, Prevention, and Incidence of Cardiovascular Disease Among Immigrant and Refugee Populations [PDF]

Manav V. Vyas, Vanessa Redditt, Sebat Mohamed, Mosana Abraha, Javal Sheth, Baiju R. Shah, Dennis T. Ko, Calvin Ke   +7 more
openalex   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Psychosocial determinants of contraceptive desire and use among sexually-active adolescent girls in Kenya and Nigeria: implications for girl-centered contraceptive programs. [PDF]

Contracept Reprod Med
Musau A, Schlingemann S, Odeh R, Ndungu L, Bulama A, Momanyi H, Cutherell M, Tele A, Biesma R, Stekelenburg J.   +9 more
europepmc   +1 more source

Determinants of puerperal sepsis among postpartum women: a case–control study in East Shoa Zone public hospitals, Central Ethiopia [PDF]

Befekadu Tesfaye Oyato, Tirunesh Debele, Dejene Edosa, Husen Zakir Abasimel, Mukemil Awol, Eleni Tesfaye Kebede, Andualem Gezahagn, Adugna Alemu Desta, Fikadu Tolesa Alemu, Samuel Boja Asfaw   +9 more
openalex   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Correction: Patterns of utilization and determinants of maternal health services among women residing in low-income communities in Lagos State, Nigeria. [PDF]

PLOS Glob Public Health
Olubodun T, Owolabi O, Adejugbe O, Iroko O, Uwalaka C, Afolabi B.   +5 more
europepmc   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source