Results 81 to 90 of about 733,924 (247)

Multimorbidity and its correlates in middle-aged and older adults in a city of North India

Journal of Family Medicine and Primary Care
Context: Multimorbidity (MM), defined as the presence of two or more chronic health conditions in an individual, can be more burdensome than single chronic disease.
Asra Saqib, Tabassum Nawab, Anees Ahmad, Najam Khalique   +3 more
doaj   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Trends in influenza vaccination and its determinants among pregnant French women between 2015 and 2020: A single-center study

Human Vaccines & Immunotherapeutics
In 2016, only 7% of French women had received an influenza vaccination during their pregnancy. In this vaccine-averse country, the possibility of reaching the rates of 50% observed in other countries remains unknown.
Khadija Alaoui, Sophie Vanderstichele, Stéphanie Bartolo, Yamina Hammou, Véronique Debarge, Rodrigue Dessein, Karine Faure, Damien Subtil   +7 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Determinants of Statin Initiation Among Adult Diabetic Patients in Bonga, Ethiopia

Diabetes, Metabolic Syndrome and Obesity, 2020
Bezie Kebede zelalem, Desalegn Feyisa School of Pharmacy, College of Health Science, Mizan-Tepi University, Mizan-Teferi, EthiopiaCorrespondence: Bezie Kebede zelalem Tel +251 921279910Email beza.kebede21@gmail.comBackground: Diabetes mellitus (DM) is a ...
Kebede zelalem B, Feyisa D
doaj  

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Cancer Awareness and Screening Practices of Ghanaian Adults: A Cross‐Sectional Survey

Cancer Reports
Background Cancer screening has been identified as an important contributor to cancer prevention and the control of both morbidity and mortality from cancer. Despite its importance, screening rates have remained low in Ghana. This study investigated some
Patrick Kafui Akakpo, Martin Gameli Akakpo   +1 more
doaj   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source