Results 101 to 110 of about 13,501,965 (257)

Sex determination in Aedes aegypti.

, 2011
We proposed an hypothetical model for sex determination in Aedes that is presented here. In this model we hypothesized the existence of two different upstream regulators that we named SR-M and SR-F (SR is for Splicing Regulator, not necessarily an SR ...
SALVEMINI, MARCO, D'AMATO, ROCCO, PETRELLA, VALERIA, SACCONE, GIUSEPPE, POLITO, CATELLO   +4 more
core  

Determining the Chronological Age of Children Living in the Mediterranean Region Using Different Radiological Methods and Age Estimation Methods

Journal of Behçet Uz Children's Hospital
Objective: The aim of this study was to evaluate the suitability of three age estimation methods, using different radiological techniques, for estimating the chronological age (CA) of children living in the Mediterranean region, and whether these methods
Berna Kuter, Ceren Sağlam, Fahinur Ertuğrul, Neşe Güler   +3 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Toward a Sovereign Afghanistan

, 2011
Focusing on four key issue areas relevant to the immediate and near future of Afghanistan including governance and economy, identity, reconciliation and reintegration, and the region and macro region, the Liechtenstein Institute on Self-Determination ...
Liechtenstein Institute on Self-Determination
core  

An effective method for the determination of the locking range of an injection-locked frequency divider [PDF]

, 2008
The paper proposes a methodology for the determination of the locking range of an Injection-Locked Frequency Divider. The technique involves the use of the Warped Multi-time scale model and is applicable to oscillators in general.
Xu, Tao, Condon, Marissa
core   +2 more sources

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Universal method for contact fatigue determination

MethodsX
In the process of contact wear, pitting is formed, which destroys the surface of the part. Existing methods for assessing contact fatigue (GOST 25.501–78, R 50–54–30–87) reveal a stress level at which pitting does not occur. At the same time, there is no
Igor Stepankin, Abdrakhman Naizabekov, Evgeniy Pozdnyakov, Dmitry Kuis, Sergey Lezhnev, Yevgeniy Panin   +5 more
doaj   +1 more source