Results 91 to 100 of about 17,466 (191)
The Role of miRNAs in Chicken Immune Regulation and Prospects for Disease‐Resistant Breeding
Animal Research and One Health, EarlyView.A schematic workflow illustrating the screening of disease‐resistant miRNAs and the generation of miRNA‐based disease‐resistant chickens via PGC‐mediated germline genome editing. ABSTRACT MicroRNAs (miRNAs) are emerging as pivotal regulators of the immune system, playing a decisive role in shaping disease resistance in chicken.
Qiangzhou Wang +10 more
wiley +1 more source
Shanghai Jiaotong Daxue xuebao. Yixue banObjective·To construct truncations of CYLD, and to preliminarily analyze their effects on the proliferation of gastric cancer cells.Methods·TCGA, GTEx, and Kaplan-Meier Plotter databases were used to analyze the differences in the expression levels of ...
Nadina PAERHATI +4 more
doaj +1 more source
Animal Research and One Health, EarlyView.Basic research on the PEDV infection cycle and virus–host interactions advances the development of anti‐PEDV drugs and disease‐resistant breeding and helps strengthen disease prevention and control while reducing economic losses in the swine industry.
Heyong Wu +8 more
wiley +1 more source
Identification Of Small Molecule TRABID Deubiquitinase Inhibitors By Computation-Based Virtual Screen [PDF]
, 2012 BackgroundWnt/β-catenin-mediated gene transcription plays important roles in a wide range of biological and pathophysiological processes including tumorigenesis where β-catenin-mediated transcription activity frequently elevates. TRABID, a deubiquitinase,
Dianqing Wu +9 more
core +1 more source
BiomoleculesBabesia microti is the primary agent of human babesiosis, an emerging tick-borne disease with limited treatment options and growing evidence of drug resistance.
Betül Yusuf, Fatih Kocabaş
doaj +1 more source
A High-Throughput Assay for Monitoring Ubiquitination in Real Time
Frontiers in Chemistry, 2019 Protein ubiquitination is a highly orchestrated process that controls diverse aspects of human biology. Dysregulation of this process can lead to various disease states including cancer, neurodegeneration, and autoimmunity.
Tyler G. Franklin, Jonathan N. Pruneda
doaj +1 more source
Epigenetic Regulation in the Pathogenesis of Renal Inflammation: Insights and Therapeutic Potentials
iNew Medicine, EarlyView.ABSTRACT Renal inflammation is a common pathological process in various kidney diseases, often initiated by factors such as toxins, ischemia, or autoimmune reactions. This inflammatory response can result in structural damage and a rapid decline in renal function.
Yu‐Hang Dong +5 more
wiley +1 more source
Clinical and Translational MedicineRationale Metastatic head and neck squamous cell carcinoma (mHNSCC) poses a significant threat to patient survival. Previous studies have identified cathepsin L (CTSL) as a key driver of tumourigenesis, metastasis and chemoresistance.
Lunhua Guo +7 more
doaj +1 more source
Deubiquitinase USP38 Stabilizes PLK1 Expression to Boost DNA Damage Repair in Ovarian Cancer
The Kaohsiung Journal of Medical Sciences, EarlyView.ABSTRACT Ovarian cancer (OC) is one of the most prevalent and severe gynecological malignant tumors. DNA damage repair (DDR) is essential in maintaining genome stability. This study aims to investigate the effects and mechanisms of USP38 and PLK1 on DNA damage repair and malignant behavior in OC cells.
Yuan Ma, Ying Li, Kai‐Li Li
wiley +1 more source
The deubiquitinase USP35: from an oncogenic hub to a therapeutic target in human cancers
Frontiers in OncologyUbiquitination is a critical post-translational modification in eukaryotic cells, mediated by a sequential enzymatic cascade involving E1 (activating), E2 (conjugating), and E3 (ligase) enzymes that catalyze the covalent conjugation of ubiquitin to ...
Bisheng Li +6 more
doaj +1 more source