Results 101 to 110 of about 17,466 (191)
Recent Developments in Cell Permeable Deubiquitinating Enzyme Activity-Based Probes
Frontiers in Chemistry, 2019 Deubiquitinating enzymes (DUBs) function to remove or cleave ubiquitin from post-translationally modified protein substrates. There are about 100 known DUBs in the proteome, and their dysregulation has been implicated a number of disease states, but the ...
Daniel Conole +3 more
doaj +1 more source
Gentiopicroside Regulates EGFR and Induces Its Lysosomal Degradation to Attenuate Heart Failure
Phytotherapy Research, EarlyView.GPS attenuates pressure overload‐induced cardiac remodeling by promoting lysosomal degradation of EGFR. TAC‐induced EGFR accumulation activates AKT/ERK1/2 signaling and drives pathological cardiac hypertrophy, fibrosis, apoptosis, oxidative stress, and cardiac dysfunction. GPS promotes lysosome‐dependent EGFR degradation, thereby limiting excessive AKT/
Mingzhen Cao +6 more
wiley +1 more source
, 2018 Deubiquitinase family proteins are broadly involved in modulating antiviral response through dynamic and diverse mechanisms.
Yunfei Qin +6 more
core +1 more source
Small molecule deubiquitinase inhibitors promote macrophage anti-infective capacity. [PDF]
, 2014 The global spread of anti-microbial resistance requires urgent attention, and diverse alternative strategies have been suggested to address this public health concern.
Christiane E. Wobus (125963) +11 more
core +1 more source
Smart Molecules, EarlyView.The CD47–SIRPα axis has emerged as a critical innate immune checkpoint that suppresses macrophage‐mediated phagocytosis through a canonical “don't eat me” signal and enables tumor immune evasion. We comprehensively summarize the structural and biological features of CD47 and the molecular mechanisms underlying CD47‐mediated regulation of phagocytosis ...
Ruimei Zhou +4 more
wiley +1 more source
Advances in Cytosolic dsRNA Sensing of Viral Infections
Immunology &Cell Biology, EarlyView.Activation of cytosolic dsRNA sensors by viral infection generates multiple outcomes. dsRNA generated during viral infection, either of viral origin or from endogenous sources, can activate multiple cytosolic dsRNA sensors. Activation of PKR critically induces protein translation shutdown via phosphorylation of eukaryotic translation initiation factor ...
Sofia Maceratessi, Natalia G. Sampaio
wiley +1 more source
Translating cardiovascular ion channel and Ca2+ signalling mechanisms into therapeutic insights
The Journal of Physiology, EarlyView.Abstract figure legend This white paper integrates mechanistic discoveries across ion channel biology, Ca2+ signalling and multiscale cardiovascular physiology to highlight new opportunities for accelerating research and guiding next‐generation therapies. Printed with permission from ®Anita Impagliazzo Medical Illustration. [Correction added on 2 March
Silvia Marchianò +18 more
wiley +1 more source
Protein Science, Volume 35, Issue 11, November 2026.Abstract Eukaryotic proteomes are regulated by the ubiquitin‐proteasome system. Unwanted proteins are tagged with ubiquitin, which is recognized by the 26S proteasome for degradation. To enter the proteasome's 20S core particle and be hydrolyzed into peptides, the substrate must be unfolded and threaded through the 19S regulatory particle.
Edwin R. Ragwan +4 more
wiley +1 more source
Monoubiquitination of ASXLs controls the deubiquitinase activity of the tumor suppressor BAP1. [PDF]
, 2018 peer reviewedThe tumor suppressor and deubiquitinase (DUB) BAP1 and its Drosophila ortholog Calypso assemble DUB complexes with the transcription regulators Additional sex combs-like (ASXL1, ASXL2, ASXL3) and Asx respectively.
Bonneil, Eric +18 more
core +2 more sources
Arthritis &Rheumatology, Volume 78, Issue 10, Page 2149-2159, October 2026.Objective Still disease represents a prototypical polygenic systemic autoinflammatory disease, characterized by recurrent systemic inflammation and dysregulation of innate immunity. Despite extensive clinical characterization, familial clustering Still disease remains unreported.
Longfang Chen +23 more
wiley +1 more source