Results 121 to 130 of about 17,466 (191)

Identification and characterization of a proteasome deubiquitinase inhibitor

, 2014
The 26S proteasome has emerged as an attractive therapeutic target in the treatment of cancers. Proteasome inhibitors have been shown to selectively kill cancer cells.
Slavica Brnjic (18685201)
core   +1 more source

Identification of Salmonella Typhimurium Deubiquitinase SseL Substrates by Immunoaffinity Enrichment and Quantitative Proteomic Analysis

, 2015
Ubiquitination is a key protein post-translational modification that regulates many important cellular pathways and whose levels are regulated by equilibrium between the activities of ubiquitin ligases and deubiquitinases.
Ryan L. Sontag (1538644), Ernesto S. Nakayasu (1538647), Tiago J. P. Sobreira (1538626), Joshua N. Adkins (39312), Daniel R. Humphrys (1538629), Michael A. Sydor (1538638), Rosa Di Leo (49394), Brooke L. Deatherage Kaiser (1538641), Olena Onoprienko (1538632), Charles Ansong (175364), Eric D. Cambronne (1538635), Roslyn N. Brown (173094), Alexei Savchenko (209003), Richard D. Smith (39311), Gordon W. Slysz (1348992), Tatiana Skarina (246836), Jie Li (15030)   +16 more
core   +1 more source

USP20 mediates malignant phenotypic changes in bladder cancer through direct interactions with YAP1

Neoplasia: An International Journal for Oncology Research
Yes-associated protein 1 (YAP1) has attracted attention for its potential in the treatment of various types of malignancies. The Hippo-YAP1 axis is inhibited in bladder cancer (BC), which is a major driver of BC progression and oncogenesis. Hippo pathway
Wensun Chen, Siqi Wu, Yifan Chen, Weijian Li, Yiqing Cao, Yingchun Liang, Xiyu Dai, Xinan Chen, Yilin Chen, Tian Chen, Shenghua Liu, Chen Yang, Haowen Jiang   +12 more
doaj   +1 more source

The histone deubiquitinase OTLD1 targets euchromatin to regulate plant growth

, 2016
Histone monoubiquitination is associated with active chromatin and plays an important role in epigenetic regulation of gene expression in plants. Deubiquitinating enzymes remove the ubiquitin group from histones and thereby contribute to gene repression.
Citovsky, Vitaly, Keren, Ido
core   +1 more source

OTUB1-mediated inhibition of ubiquitination: a growing list of effectors, multiplex mechanisms, and versatile functions

Frontiers in Molecular Biosciences
Protein ubiquitination plays a pivotal role in protein homeostasis. Ubiquitination may regulate the stability, activity, protein–protein interaction, and localization of a protein.
Miaomiao Wu, Lidong Sun, Lidong Sun, Tanjing Song, Tanjing Song   +4 more
doaj   +1 more source

Chimeric deubiquitinase engineering reveals structural basis for specific inhibition of USP30 and a framework for DUB ligandability

The mitochondrial deubiquitinase USP30 negatively regulates Pink1/Parkin-driven mitophagy. Whether enhanced mitochondrial quality control through inhibition of USP30 can protect dopaminergic neurons is currently explored in a clinical trial for Parkinson’
Kazi, Nafizul Haque, Kipka, Gian-Marvin, Gersch, Malte, Gallant, Kai; id_orcid, Klink, Nikolas   +4 more
core   +1 more source

Deubiquitinase-Targeting Chimera (DUBTAC)-Enhanced Mammalian Expression System for Efficient Recombinant Protein Expression

Overexpression of exogenous proteins in mammalian cells frequently saturates the endogenous folding and quality control machinery, resulting in their recognition as misfolded substrates, subsequent polyubiquitination, and rapid degradation by the 26S ...
Ruhu Zheng, Yicong Dai, Xucong Teng, Xuan Zhao, Qiushuang Zhang, Jinghong Li   +5 more
core   +1 more source

Deubiquitinase Usp12 functions noncatalytically to induce autophagy and confer neuroprotection in models of Huntington's disease.

, 2018
Huntington's disease is a progressive neurodegenerative disorder caused by polyglutamine-expanded mutant huntingtin (mHTT). Here, we show that the deubiquitinase Usp12 rescues mHTT-mediated neurodegeneration in Huntington's disease rodent and patient ...
P Pellegrini (7754096), R Aron (7754093), AC Daub (7754111), K Opoku-Nsiah (7754105), F Giorgini (7735205), JS Wong (7754108), DC Maddison (7754102), EW Green (7754099), S Finkbeiner (7754114)   +8 more
core   +1 more source

PSMD14 as a translational target in cancer and beyond: from deubiquitination mechanisms to drug resistance and precision therapy. [PDF]

Cancer Drug Resist
Liu H, Ma L, Wang Y, Wang Y, Chen S, Wang M, Cao D, Chen Y, Si W.   +8 more
europepmc   +1 more source

Author Correction: Structural dynamics of the midnolin-proteasome during ubiquitin-independent substrate turnover. [PDF]

Nat Commun
Zhu C, Qin L, Dai Z, Zuo P, Yang A, Zhong L, Lin Z, Liang L.   +7 more
europepmc   +1 more source