Results 61 to 70 of about 27,265 (285)

The centrosomal deubiquitylase USP21 regulates Gli1 transcriptional activity and stability [PDF]

, 2016
USP21 is a centrosome-associated deubiquitylase (DUB) that has been implicated in the formation of primary cilia - crucial organelles for the regulation of the Hedgehog (Hh) signaling pathway in vertebrates. Here, we identify KCTD6 - a cullin-3 E3-ligase
Bertsoulaki, Erithelgi, Clague, Michael J., Cucchi, Danilo, DE SMAELE, Enrico, Heride, Claire, Rigden, Daniel J., Urbé, Sylvie   +6 more
core   +1 more source

Characterization and Noncovalent Inhibition of the Deubiquitinase and deISGylase Activity of SARS-CoV-2 Papain-Like Protease

ACS Infectious Diseases, 2020
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent for COVID-19, is a novel human betacoronavirus that is rapidly spreading worldwide. The outbreak currently includes over 3.7 million cases and 260,000 fatalities.
Brendan T. Freitas, Ian A. Durie, J. Murray, Jaron E. Longo, H. Miller, D. Crich, R. Hogan, R. Tripp, S. Pegan   +8 more
semanticscholar   +1 more source

Targeting deubiquitinases for cancer therapy

Clinical and Translational Discovery, 2023
AbstractThe ubiquitin‐proteasome system assumes a critical role in numerous cellular processes, and among its components, deubiquitinases (DUBs) have emerged as essential regulators. With roughly 100 DUBs encoded within the human genome, these enzymes can be categorized into two main types: cysteine protease DUBs and metalloproteinase DUBs, based on ...
Qian Xue, Daolin Tang, Xin Chen, Jinbao Liu   +3 more
openaire   +2 more sources

Regulation of NF‐κB by deubiquitinases [PDF]

Immunological Reviews, 2012
Summary: The nuclear factor‐κB (NF‐κB) pathway is a critical regulator of innate and adaptive immunity. Noncanonical K63‐linked polyubiquitination plays a key regulatory role in NF‐κB signaling pathways by functioning as a scaffold to recruit kinase complexes containing ubiquitin‐binding domains.
Edward W, Harhaj, Vishva M, Dixit
openaire   +2 more sources

The replicative lifespan-extending deletion of SGF73 results in altered ribosomal gene expression in yeast. [PDF]

, 2017
Sgf73, a core component of SAGA, is the yeast orthologue of ataxin-7, which undergoes CAG-polyglutamine repeat expansion leading to the human neurodegenerative disease spinocerebellar ataxia type 7 (SCA7).
Garza, Renee M, Kennedy, Brian K, La Spada, Albert R, Mason, Amanda G, McCormick, Mark A, Patel, Bhumil, Pillus, Lorraine   +6 more
core   +2 more sources

Targeting deubiquitinase USP28 for cancer therapy [PDF]

Cell Death & Disease, 2018
AbstractAs one of the most important post-translational modifications, ubiquitination plays versatile roles in cancer-related pathways, and is involved in protein metabolism, cell-cycle progression, apoptosis, and transcription. Counteracting the activities of the E3 ligases, the deubiquitylating enzymes have been suggested as another important ...
Wang, Xiaofang, Liu, Zhiyi, Zhang, Li, Yang, Zhaozhi, Chen, Xingxing, Luo, Jurui, Zhou, Zhirui, Mei, Xin, Yu, Xiaoli, Shao, Zhimin, Feng, Yan, Fu, Shen, Zhang, Zhen, Wei, Dongping, Jia, Lijun, Ma, Jinli, Guo, Xiaomao   +16 more
openaire   +2 more sources

Glutamatergic CYLD deletion leads to aberrant excitatory activity in the basolateral amygdala: association with enhanced cued fear expression

Neural Regeneration Research
Neuronal activity, synaptic transmission, and molecular changes in the basolateral amygdala play critical roles in fear memory. Cylindromatosis (CYLD) is a deubiquitinase that negatively regulates the nuclear factor kappa-B pathway.
Huidong Li, Faqin Li, Zhaoyi Chen, Erwen Wu, Xiaoxi Dai, Danni Li, Haojie An, Shiyi Zeng, Chunyan Wang, Li Yang, Cheng Long   +10 more
doaj   +1 more source

Roles of tumor suppressors in regulating tumor-associated inflammation. [PDF]

, 2014
Loss or silencing of tumor suppressors (TSs) promotes neoplastic transformation and malignant progression. To date, most work on TS has focused on their cell autonomous effects.
Karin, M, Yang, L
core   +1 more source

Deubiquitinase OTUD3 regulates metabolism homeostasis in response to nutritional stresses.

Cell Metabolism, 2022
The ovarian-tumor-domain-containing deubiquitinases (OTUDs) block ubiquitin-dependent protein degradation and are involved in diverse signaling pathways.
Na Zhou, Hailong Qi, Junjun Liu, Guangze Zhang, Jianping Liu, Ning Liu, Minglu Zhu, Xuyang Zhao, Chang Song, Zhe Zhou, Jingjing Gong, Ridong Li, Xinyu Bai, Yan Jin, Yongfeng Song, Yuxin Yin   +15 more
semanticscholar   +1 more source

Screen for ISG15-crossreactive Deubiquitinases

PLoS ONE, 2007
The family of ubiquitin-like molecules (UbLs) comprises several members, each of which has sequence, structural, or functional similarity to ubiquitin. ISG15 is a homolog of ubiquitin in vertebrates and is strongly upregulated following induction by type I interferon.
Catic, Andre, Fiebiger, Edda, Korbel, Gregory, Blom, Daniël, Galardy, Paul J., Ploegh, Hidde L.   +5 more
openaire   +5 more sources