Results 51 to 60 of about 17,466 (191)

USP16 counteracts mono-ubiquitination of RPS27a and promotes maturation of the 40S ribosomal subunit

eLife, 2020
Establishment of translational competence represents a decisive cytoplasmic step in the biogenesis of 40S ribosomal subunits. This involves final 18S rRNA processing and release of residual biogenesis factors, including the protein kinase RIOK1.
Christian Montellese, Jasmin van den Heuvel, Caroline Ashiono, Kerstin Dörner, André Melnik, Stefanie Jonas, Ivo Zemp, Paola Picotti, Ludovic C Gillet, Ulrike Kutay   +9 more
doaj   +1 more source

Ubiquitin-Specific Peptidase 7: A Novel Deubiquitinase That Regulates Protein Homeostasis and Cancers

Frontiers in Oncology, 2021
Ubiquitin-Specific Peptidase 7 (USP7), or herpes virus-associated protease (HAUSP), is the largest family of the deubiquitinating enzymes (DUBs). Recent studies have shown that USP7 plays a vital role in regulating various physiological and pathological ...
Lin Zhou, Taohui Ouyang, Meihua Li, Tao Hong, Alriashy MHS, Wei Meng, Na Zhang   +6 more
doaj   +1 more source

Microprotein MP104 Promotes Malignant Progression of Colorectal Cancer Through Regulating Protein Translation

Advanced Science, EarlyView.
A previously unrecognized microprotein, MP104, encoded by ZEB1‐AS1, emerges as a critical driver of colorectal cancer progression. MP104 links ubiquitin‐mediated protein degradation with translational reprogramming via the UBE2O–AMPKα2–mTOR–EIF4B axis, revealing an unrecognized layer of oncogenic regulation.
Fang Chen, Miao Wang, Hongmei Yong, Jin Ding, Shiping Xu, Qirui Ge, Yan Wang, Lei Zhang, Qianqian Xiao, Benli Li, Li Lin, Sufang Chu, Qianqing Wang, Jin Bai, Pingfu Hou   +14 more
wiley   +1 more source

EZH2 Inhibition Enhances PD‐L1 Protein Stability Through USP22‐Mediated Deubiquitination in Colorectal Cancer

Advanced Science
The regulation of PD‐L1 is the key question, which largely determines the outcome of the immune checkpoint inhibitors (ICIs) based therapy. However, besides the transcription level, the protein stability of PD‐L1 is closely correlated with its function ...
Jiaqi Huang, Qianqian Yin, Yuqing Wang, Xin Zhou, Yunyun Guo, Yuanjun Tang, Rui Cheng, Xiaotong Yu, Jie Zhang, Chen Huang, Zhanya Huang, Jianlin Zhang, Zhengyang Guo, Xiao Huo, Yan Sun, Yanfang Li, Hao Wang, Jianling Yang, Lixiang Xue   +18 more
doaj   +1 more source

Dysregulation of ubiquitination modification in renal cell carcinoma

Frontiers in Genetics
Renal cell carcinoma (RCC) is a malignant tumor of the renal tubular epithelial cells with a relatively high incidence rate worldwide. A large number of studies have indicated that dysregulation of the ubiquitination, including ubiquitination and ...
Hongjie You, Hui Zhang, Xiaofeng Jin, Zejun Yan   +3 more
doaj   +1 more source

Broad Spectrum Deubiquitinase Inhibition Induces Both Apoptosis and Ferroptosis in Cancer Cells

Frontiers in Oncology, 2020
Proteasomal deubiquitinase (DUB) inhibition has been found to be effective in experimental cancer therapy by inducing proteasome inhibition and apoptosis. Ferroptosis is a form of regulated cell death characterized by an iron-dependent lipid peroxidation.
Li Yang, Li Yang, Xin Chen, Qianqian Yang, Jinghong Chen, Jinghong Chen, Qingtian Huang, Leyi Yao, Ding Yan, Jiawen Wu, Peiquan Zhang, Daolin Tang, Nanshan Zhong, Jinbao Liu   +13 more
doaj   +1 more source

SARS-CoV-2 Spike Targets USP33-IRF9 Axis via Exosomal miR-148a to Activate Human Microglia

Frontiers in Immunology, 2021
SARS-CoV-2, the novel coronavirus infection has consistently shown an association with neurological anomalies in patients, in addition to its usual respiratory distress syndrome.
Ritu Mishra, Akhil C. Banerjea
doaj   +1 more source

Nanoparticle‐Mediated TIPE1 mRNA Delivery Enhances Paclitaxel Sensitivity in Triple‐Negative Breast Cancer by Modulating RAB7A Ubiquitination‐Associated Stability and Autophagy

Advanced Science, EarlyView.
TIPE1m NPs nanoparticles restore TIPE1 expression, promote RAB7A ubiquitination and degradation, suppress autophagic flux, and resensitize paclitaxel‐resistant triple‐negative breast cancer to therapy. ABSTRACT Acquired paclitaxel (PTX) resistance remains a major obstacle in triple‐negative breast cancer (TNBC) treatment.
Wei Hu, Qishuai Chen, Yan Ma, Yang Liu, Xianing Dong, Wenjuan Wei, Jianxin Du, Shusheng Qiu, Maojin Tian, Peiqing Zhao   +9 more
wiley   +1 more source

The deubiquitinase USP38 affects cellular functions through interacting with LSD1

, 2018
Background Deubiquitination is a posttranslational protein modification prevalent in mammalian cells. Deubiquitinases regulate the functions of the target protein by removing its ubiquitin chain.
Yanan Wang, Qi Zhang, Yuanyuan Fang, Wenbin Liu   +3 more
core   +1 more source

Deubiquitinase FAM/USP9X interacts with the E3 ubiquitin ligase SMURF1 protein and protects it from ligase activity-dependent self-degradation [PDF]

, 2012
Background: SMURF1 ubiquitin ligase controls ubiquitination and stability of diverse cellular protein substrates. Results: Deubiquitinase USP9X interacts with SMURF1 and stabilizes SMURF1 through deubiquitination.
Wilson, Christopher, Feng, Yan, Schirle, Markus, Bric-Furlong, Eva, Kirschner, Marc W, Xie, Yang, Nathans, Robin, Cong, Feng, Zhang, Jing, Huang, Shih-Min A, Avello, Monika, Whinnie, Elizabeth Mc, Huang, Shih-Min   +12 more
core   +1 more source