Results 61 to 70 of about 17,466 (191)

USP38 Inhibits Zika Virus Infection by Removing Envelope Protein Ubiquitination

Viruses, 2021
Zika virus (ZIKV) is a mosquito-borne flavivirus, and its infection may cause severe neurodegenerative diseases. The outbreak of ZIKV in 2015 in South America has caused severe human congenital and neurologic disorders.
Yingchong Wang, Qin Li, Dingwen Hu, Daolong Gao, Wenbiao Wang, Kailang Wu, Jianguo Wu   +6 more
doaj   +1 more source

circZNF148 Drives Glucose Metabolism Reprogramming to Enhance Metastasis and Immune Evasion via HK1 Stabilization in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
CircZNF148 stabilizes HK1 through deubiquitinase recruitment, thereby enhancing glycolysis and lactate production. Elevated lactate promotes PD‑L1 lactylation and membrane accumulation while suppressing CD8+ T‐cell cytotoxicity, collectively facilitating immune evasion and malignant progression in TNBC.
Yuhan Jin, Wenjing Zhao, Lei Wang, Jianing Wang, Keying Zhao, Dan Luo, Yifei Wang, Yuxia Yang, Jingze Yang, Yaming Li, Tong Chen, Dianwen Han, Zekun Wang, Xiaoyan Li, Bing Chen, Lijuan Wang, Yiran Liang, Qifeng Yang   +17 more
wiley   +1 more source

Targeting the deubiquitinase STAMBP inhibits NALP7 inflammasome activity

, 2017
Inflammasomes regulate innate immune responses by facilitating maturation of inflammatory cytokines, interleukin (IL)-1β and IL-18. NACHT, LRR and PYD domains-containing protein 7 (NALP7) is one inflammasome constituent, but little is known about its ...
Dexter L. Gulick, Rama K. Mallampalli, Nathaniel Weathington, SeungHye Han, Robert Fort, Alison C. McKelvey, James Londino, Mauricio Rojas, Joseph S. Bednash, Bill B. Chen   +9 more
core   +1 more source

Metabolic Reprogramming in Glioblastoma Stem Cells Promotes Radiation Resistance Through a H3K18la/USP30/MBOAT2 Axis

Advanced Science, EarlyView.
LDHA‐driven lactate production in mesenchymal glioma stem cells promotes p300‐dependent H3K18 lactylation, activates USP30 transcription, and stabilizes MBOAT2 to remodel phosphatidylethanolamines toward ferroptosis‐resistant PE‐MUFA species. Disrupting this metabolic–epigenetic–lipid circuit enhances ferroptosis and sensitizes glioblastoma to ...
Zong Miao, Wei Gu, Yimin Ren, Chenfei Lu, Wanzhi Cai, Junnan Lu, Zhongyuan Bao, Yanan Zhou, Rong Li, Ke Jin, Chao Chen, Hongxiang Wang, Lei Xu, Juxiang Chen   +13 more
wiley   +1 more source

Additional file 2: of Mice null for the deubiquitinase USP18 spontaneously develop leiomyosarcomas

, 2016
Mice Null for the Deubiquitinase USP18 Spontaneously Develop Leiomyosarcoma.
Vincent Memoli (3521477), Wendy Wells (683793), Fadzai Chinyengetere (3521486), Masanori Kawakami (3521495), Paul Hoopes (3521489), Tian Ma (430725), Sarah Freemantle (3227), Burton Eisenberg (3521483), Alexander Lazar (3521471), Aarti Sanglikar (3521468), Yun Lu (210518), Keila Torres (250237), Sandra Burkett (68309), David Sekula (3521480), Elizabeth Demicco (3521492), Ethan Dmitrovsky (3230), Andrew Giustini (3521474)   +16 more
core   +1 more source

The deubiquitinase ElaD is present in the majority of Escherichia coli strains

Frontiers in Microbiology
BackgroundPathogens employ a variety of effectors to modulate key host signaling pathways, thereby facilitating bacterial survival and enhancing pathogenicity.
Xinyu Wang, Weiqi Guo, Jiangang Hu, Beibei Zhang, Jingjing Qi, Mingxing Tian, Yanqing Bao, Lei Deng, Shaohui Wang   +8 more
doaj   +1 more source

OTUD6A‐Mediated Deubiquitination of PRDX1 Protects Against Oral Ulcer by Restoring Mitochondrial Function

Advanced Science, EarlyView.
In human oral keratinocytes, OTUD6A promoted cell migration by deubiquitinating and stabilizing PRDX1. Conversely, OTUD6A deficiency reduced PRDX1 stability, triggering mitochondrial dysfunction and aggravating OU progression. ABSTRACT Oral ulcers (OU), as the most highly prevalent and recurrent oral mucosal lesion, have an unclear pathogenesis that ...
Xiaoyu Sun, Ruiwei Jia, Xingbei Pan, Rui Huang, Jiahong Chen, Ziyi Yao, Lei Yin, Jun Ma, Hongjieliang Wang, Xinyu Huang, Yilin Ma, Yifan Ping, Yuanyuan Chen, Huining Wang, Shengbin Huang, Guang Liang   +15 more
wiley   +1 more source

USP30‐Mediated Deubiquitination of PEX5 Suppresses Pexophagy to Drive Tubular Injury in Diabetic Kidney Disease

Advanced Science, EarlyView.
USP30 accumulation in diabetic renal tubular epithelial cells deubiquitinates PEX5, suppresses pexophagy, and drives dysfunctional peroxisome accumulation and tubular injury. USP30 depletion restores PEX5 ubiquitination and pexophagy, improves peroxisomal function, and alleviates tubular damage, highlighting USP30 as a therapeutic target in diabetic ...
Jia Li, Chaoyang Hua, Guangpu Li, Furong Zhai, Jingjing Ren, Shaokang Pan, Qi Feng, Jianguo Wen, Dongwei Liu, Zhangsuo Liu, Jiayu Duan   +10 more
wiley   +1 more source

USP7-Based Deubiquitinase-Targeting Chimeras Stabilize AMPK

Deubiquitinase-targeting chimeras (DUBTACs) have been recently developed to stabilize proteins of interest, which is in contrast to targeted protein degradation (TPD) approaches that degrade disease-causing proteins.
Li Chen (5749), Wenyi Wei (6911471), Zhen Wang (72451), Xiaoping Hu (231981), Xufen Yu (1570180), Joao A. Paulo (397190), Kaixiu Luo (6159407), Yan Xiong (197517), Chao Qian (785841), Jing Liu (38537), Jian Jin (351142), Hiroyuki Inuzuka (12378227), Xian Chen (107385), Dingpeng Zhang (6052529), Adil Muneer (18338096), Ling Xie (2026981)   +15 more
core   +1 more source

Biochemical and functional analysis of the ubiquitin binding properties of the NF-κB regulator NEMO [PDF]

, 2013
Many types of ubiquitin chains can modify several proteins at the activated TNFR. Additionally many UBD-containing ubiquitin receptors localise there to mediate the signal constituted by these chains.
Kensche, Tobias
core