Results 31 to 40 of about 17,466 (191)
A Herpesvirus Encoded Deubiquitinase Is a Novel
Neuroinvasive Determinant [PDF]
, 2009 The neuroinvasive property of several alpha-herpesviruses underlies an uncommon infectious process that includes the establishment of life-long latent infections in sensory neurons of the peripheral nervous system.Lee Joy I., Lee, Joy I., Baver, Scott B., Sollars, Patricia J., Smith, Gregory A., Joy I Lee, Sollars Patricia J., Smith Gregory A., Scott B Baver, Gregory A. Smith, Patricia J Sollars, Pickard Gary E., Patricia J. Sollars, Gary E. Pickard, Leelawong Mindy, Scott B. Baver, Gregory A Smith, Baver Scott B., Leelawong, Mindy, Pickard, Gary E., Joy I. Lee, Mindy Leelawong, Gary E Pickard +22 morecore +2 more sourcesTargeting USP42 induces DNA damage and inhibits cell growth in prostate cancer
Frontiers in Molecular BiosciencesBackgroundProstate cancer (PCa) is one of the most common cancers in men worldwide. During its progression, deubiquitination-mediated alterations in biological processes play critical roles in tumor metabolism, stem cell characteristics, immune evasion ...Yinghao Zhou, Chenchen Chen, Yibo Meng, Jianchao Ge, Shengkui Meng, Xillong Wang, Yaozong Xu, Guowei Shi, Wandong Yu, Xuetao Hu, Jun Zhang +10 moredoaj +1 more sourceCaMKII mediates recruitment and activation of the deubiquitinase CYLD at the postsynaptic density. [PDF]
, 2013 NMDA treatment of cultured hippocampal neurons causes recruitment of CYLD, as well as CaMKII, to the postsynaptic density (PSD), as shown by immunoelectron microscopy.Thomas S Reese, Soe Thein (532674), Soe Thein, K Ulrich Bayer, K. Ulrich Bayer, K. Ulrich Bayer (203686), Ayse Dosemeci, Ayse Dosemeci (444973), Jung-Hwa Tao-Cheng (444971), Thomas S. Reese, Thomas S. Reese (444972), Yan Li (23143), Jung-Hwa Tao-Cheng, Yan Li +13 morecore +1 more sourceUSP7 Promotes deubiquitination and stabilization of MyD88 to enhance immune responses
Frontiers in Immunology, 2022 Toll-like receptors (TLRs) are involved in the sensing of pathogen-associated molecular patterns (PAMPs) such as lipopolysaccharide (LPS), flagellin, unmethylated double-stranded DNA (CpG), single-stranded RNA (ssRNA) and lipoproteins.Na Zhang, Fei Wang, Gaomeng Zhang, Qi Zhang, Yuhong Liu, Qiao Wang, Mohamed Shafey Elsharkawy, Maiqing Zheng, Jie Wen, Guiping Zhao, Guiping Zhao, Qinghe Li, Qinghe Li +12 moredoaj +1 more sourceThe deubiquitinase USP9X suppresses pancreatic ductal adenocarcinoma [PDF]
, 2012 Pancreatic ductal adenocarcinoma (PDA) remains a lethal malignancy despite much progress concerning its molecular characterization. PDA tumours harbour four signature somatic mutations(1-4) in addition to numerous lower frequency genetic events of ...Brosnan, J.A., Knight, S., Cloonan, N, Aust, D., Largaespada, DA, Patch, AM, Perez-Mancera, Pedro, Ralph H Hruban, Li, A., J Lynn Fink, Taylor, D, Anthony J Gill, Silverstein, K.A.T., Grimmond, S. M., Lodewyk F. A. Wessels, Xu, C, Patrick Martin, David K Chang, De Ridder, J, Nigel A Spry, Biankin, Andrew V, Morgan, R., Nagrial, Adnan, Venessa T Chin, Wessels, L.F.A., Kevin A. T. Silverstein, de Ridder J, Rümmele P, Rust, A.G., Aust, DE, Pilarsky, C., Aust, Daniela, Wood, S.A., Ridder, Jeroen de, Biankin, A. V., Derek L. Stemple, Biankin, AVW, Simpson, SL, Knosel, T., Rusta, Alistair, John Chen, Chou, A, Yu J, Musgrove, EA, Ralph H. Hruban, van der Weyden, L., Tuveson DA, Merrett, Neil D. (R14270), Grimond, SM, Ann-Marie Patch, Nicole Cloonan, Chin, VT, Chang, David K, Skye L Simpson, Chang DK, Mark J Cowley, Chelsie O'Connor, Ivon Harliwong, Biankin, Andrew V., Goggins, Michael, Cindy Forrest, Wessels, L, Kynan Feeney, Grutzmann, R, van der Weyden, Louise, Klein, AP, Nagrial, AM, Perez-Mancera, P, Mo Ballal, Tamara Debrencini, Tuveson, DA, Ismail, K, Kristiansen, G, Largaespada, D.A., Darrin Taylor, Kristiansen, Glen, Rust, Alistair G, Ray Asghari, Matthew Anderson, Rust, AG, Idrisoglu, S, Samra, JS, Hruban, RH, Guminski, A, David J. Adams, Spencer Knight, Stemple, DL, Mona Martyn-Smith, Silverstein, KAT, Yu, J., Caroline L Cooper, Nones, K, Tuveson, D.A., Wessels LF, Hruban, R, Jones, MD, Waddell, N, Jaswinder S Samra, Ming Chai, Li, A., Louise van der Weyden, Roger J Daly, et al., Pinese, M, Chou, Angela ; https://orcid.org/, Chang, D, Knight, Spencer, Holmes, O, Cosman, Peter, Morgan, R., ten Hoeve, J. J., Allen Li, Thomas Knösel, Wessels, Lodewyk F. A., Virginia James, Stefania Beghelli, Lynn Fink, J, Herd C, Margaret A Tempero, de Ridder, J., Jianmin Wu, Daly, Roger ; https://orcid.org/, Christine A. Iacobuzio-Donahue, Kasim Ismail, David Joseph, Chang, David K., Collier LS, Robert L Sutherland, Ang Li, Pilarsky C, Jun Yu, Pérez-Mancera PA, Rümmele, P., Gongora, M, Krishna P Epari, Merrett, Neil, Asghari, R, Wilson, PJ, Rummele, Petra, Christopher J Scarlett, other, and, Tim Bruxner, Wessels, Lodewyk FA, Brosnan JA, Jeremy L Humphris, Grutzmann, Robert, Glen Kristiansen, Aust D, Christopher Christophi, Richard A Morgan, Mark Pinese, Grützmann, R., Largaespada, D. A., Pearson, JV, Adams, David J, Karin S Kassahn, Chantrill, LA, Li, Allen, Sanjay Mukhedkar, Shinn Yeung, Ten Hoeve, JJ, Aust, D., Angela Chou, Jacqueline A. Brosnan, Kettleborough, R., Adnan M Nagrial, Michael Texler, Mehrdad Nikfarjam, Silverstein, K. A., James R Eshleman, David K Miller, Andrew V. Biankin, Elizabeth A Musgrove, Rust, A. G., Amber L Johns, Iacobuzio-Donahue, C.A., Daniela Aust, Grimmond, SM, O'Connor, C, Hruban, Ralph H., Sarver, A. L., Knight S, Sean M. Grimmond, Ehsan Nourbakhsh, Lorraine A Chantrill, Charbel Sandroussi, Pajic, M, Katia Nones, Chang, D. K., Angelika Christ, Pilarsky, CP, Grützmann R, Jessica Pettit, Adams, DJ, Wu, J, Biankin, AV, Kaplan, Warren, Pérez-Mancera, P.A., Herd, C, Anderson, M, Alison P. Klein, Tuveson, David A., Wood SA, Herd, C., Knight, S, Pavey, Darren, Collaborators Australian Pancreatic Cancer Genome Initiative: Andrew V Biankin, Senel Idrisoglu, Yu, J, Biankin AV, Knosel, T, Largaespada DA, Sarver, Aaron L., Merrett, ND, de Ridder, J., Klein, A. P., Rowe, SJ, Wu, Jianmin, de Ridder, Jeroen, Blankin, AV, Gill, AJ, Musgrove, Elizabeth, Humphris, JL, Wessels, LFA, David A. Largaespada, James G Kench, R Scott Mead, Kettleborough, R, Andrew Laycock, Toon, Christopher Chien Wei ; https://orcid.org/, Sarver, Aaron L, Pedro A. Pérez-Mancera, Andrew P Barbour, Australian Pancreatic Cancer Genome Initiative, Chuan P Tan, John V Pearson, Petra Rümmele, Christian Pilarsky, Rummele, P., ten Hoeve, Jelle J, Martyn-Smith, M, Adams, D.J., Ruemmele, Petra, Pilarsky, C, Anirban Maitra, Wood, S. A., Nourbakhsh, E, Knösel, T., Chang, D.K., van der Weyden L, Christina Xu, Bastiaan DeBoer, Vincenzo Corbo, Gill, Anthony, Knight, S., ten Hoeve, J.J., Michael Hatzifotis, Collier, LS, Rooman, Ilse, Grimmond, S, Iacobuzio-Donahue CA, Johns, Amber, Lara S. Collier, Amanda Mawson, Oliver Holmes, Nourse, C, Ross Kettleborough, Rooman, I, Richard, G Morgan, Bruxner, T, Kellee Slater, Toon, C, Kristiansen, G., Jelle J. ten Hoeve, Stemple, D.L., Maria Scardoni, Nam Q Nguyen, Nicola Waddell, Wood, Stephen A, Kettleborough R, Andrew D Clouston, David K. Chang, Rust AG, Iacobuzio-Donahue, C. A., Wood, Stephen, Hoeve, Jelle J. ten, Pavlakis, N, Newell, F, Aaron L. Sarver, Stegeman, S, Cowley, Mark ; https://orcid.org/, David R Fletcher, Song, S, Silverstein, Kevin AT, Bienkin, AV, Li, Ang, Goggins M, Pajic, Marina, Adams DJ, Neil D Merrett, Li A, Largaespada, David A, Brosnan, JA, Adams, David J., Richard D Schulick, Henry C Pleass, Collier, L.S., Richard Morgan, Kristiansen, GO, Knoesel, Thomas, Henry Tang, Michael Goggins, Wood, S, Pavey, DA, Sarah J Rowe, Daly, RJ, Knosel, Thomas, Andrew V Blankin, Kristiansen, G., Wessels, L. F., ten Hoeve JJ, Grimmond SM, Scott Wood, Brosnan, J. A., Amy Chiang, Sutherland, RL, Harliwong, I, Miller, DK, Yu, Jun, Peter H Cosman, Knight, Richard, Stegeman, S., Peter J Wilson, Christopher Toon, Sarver, AL, Sarver AL, Cowley, MJ, Adams, D. J., Manning, S, van der Weyden, L., Shane Stegeman, Klein, A.P., Rita T Lawlor, Chantrill, Lorraine ; https://orcid.org/, asghari, Ray, Pilarsky, Christian, Weyden, Louise van der, Pilarsky, C., Alistair G. Rust, Sutherland, Robert, Milena Gongora, Jonathan W Fawcet, Virginia Papangelis, Li, A, Stephen A. Wood, Klein, Alison P., Biankin, A.V., Tuveson, David A, Sean M Grimmond, Klein AP, Suzanne Manning, Thomas J O'Rourke, Perez-Mancera, P. A., Christ, A, Stegeman, Shane, Rust, Alistair G., Kassahn, KS, Warren Kaplan, Hruban, R. H., Shivangi Wani, Leonard, C, Knösel T, Herd, C., Mawson, A, Goggins, M., Kettleborough, Ross, Sarver, A.L., Felicity Newell, Wani, S, Cheng, DK, Mary-Anne L Brancato, Grimmond, Sean M, Stemple, D, Stegeman, S., Colin Herd, Goggins, M, Christine A Iacobuzio-Donahue, Rummele, P, Collier, L. S., Klein, Alison P, Iacobuzio-Donahue, Christine A, Nick Pavlakis, Amitabha Das, Chris Worthley, Grimmond, S.M., Wood, SA, Johns, AL, Stemple, Derek L., Stemple, Derek L, Hruban, Ralph H, Peter Hodgkinson, Stemple, D. L., Laycock Crawford, Pettit, J, Herd, Colin, Marc D Jones, Robert Grützmann, Collier, Lara S., David A. Tuveson, Brosnan, Jacqueline A., Das, A, Ridder, Jeroen, Silverstein, Kevin, van der Weyden, L, Iacobuzio-Donahue, Christine A., Kristiansen G, Brancato, MAL, Marina Pajic, Iacobuzio-donahue, CA, Claudio Bassi, Maria Beilin, Chang, DK, Stemple DL, Scott Mead, R, Hruban RH, Brosnan, Jacqueline A, Jeroen de Ridder, Gruetzmann, Robert, Collier, Lara S, Nikolajs Zeps, Yu, J., Stegeman S, Alex Guminski, Silverstein, Kevin A. T., Kettleborough, R., Cosman, PH, Perez-Mancera, Pedro A., Andrew R Ruszkiewicz, Largaespada, David A., Duncan McLeod, Pérez-Mancera, PA, Conrad Leonard, Hruban, R.H., Morgan, Richard, Aust, D, Perez-Mancera, Pedro A, Ilse Rooman, Chang, David, Wood, Stephen A., Goggins, M., Christopher L Wolfgang, Grutzmann, R., Tuveson, D. A., Vincent W Lam, Mawson, Amanda, Sarah Song, Craig Nourse, Klein, A, Aldo Scarpa, Mark E Brooke-Smith, Darren A Pavey, Sarver, Aaron, Morgan, R, Grimmond, Sean M., ten Hoeve, Jelle J., Silverstein KA, Morgan R, Rust, A., Stemple, D., Perez-Mancera, P., Brosnan, J., Sarver, A., Silverstein, K. +472 morecore +1 more sourceDisulfiram Oxy-Derivatives Suppress Protein Retrotranslocation across the ER Membrane to the Cytosol and Initiate Paraptosis-like Cell Death
Membranes, 2022 Disulfiram (DSF) and its derivatives were here investigated as antineoplastic agents, and their important feature is the ability to influence the UPS. We have recently shown that hydroxocobalamin catalyzes the aerobic oxidation of diethyldithiocarbamate ...Marina Solovieva, Yuri Shatalin, Irina Odinokova, Olga Krestinina, Yulia Baburina, Yana Lomovskaya, Anton Pankratov, Natalia Pankratova, Olga Buneeva, Arthur Kopylov, Alexei Medvedev, Vladimir Akatov +11 moredoaj +1 more sourcePANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang +4 morewiley +1 more source
