Results 11 to 20 of about 17,466 (191)

Deubiquitinase-targeting chimeras for targeted protein stabilization. [PDF]

, 2022
Many diseases are driven by proteins that are aberrantly ubiquitinated and degraded. These diseases would be therapeutically benefited by targeted protein stabilization (TPS).
Liu, Gang, McGregor, Lynn, Wingert Plasschaert, Lindsey, Tallarico, John A, fuller, daniel, Estes, Abigail R, Spradlin, Jessica, McKenna, Jeffrey, Rowlands, David, Randal, Katelyn, Belcher, Bridget P, Rowlands, David J, Estes, Abigail, Nomura, Daniel, Ward, Carl, Nomura, Daniel K, Belcher, Bridget, Valdez Misiolek, Rachel, McGregor, Lynn M, Henning, Nathaniel, Boike, Lydia, Randal, Katelyn L, Spradlin, Jessica N, Plasschaert, Lindsey W, Frank, Andreas O, Schirle, Markus, Tallarico, John, Hesse, Matthew J, Dovala, Dustin, Wang, Feng, Henning, Nathaniel J, McKenna, Jeffrey M, Zhang, Erika, Brittain, Scott M, Hesse, Matthew, Frank, Andreas, Panidapu, Anoohya, Brittain, Scott, Ward, Carl C   +38 more
core   +1 more source

Deficiency of the CYLD Impairs Fear Memory of Mice and Disrupts Neuronal Activity and Synaptic Transmission in the Basolateral Amygdala

Frontiers in Cellular Neuroscience, 2021
Fear learning and memory are crucial for animal survival. Abnormal fear memory is a hallmark of many neuropsychiatric disorders. Appropriate neuronal activation and excitability in the basolateral amygdala (BLA) are necessary for the formation of fear ...
Hui-dong Li, Dan-ni Li, Li Yang, Cheng Long, Cheng Long   +4 more
doaj   +1 more source

Deubiquitinases in Neurodegeneration

Cells, 2022
Ubiquitination refers to the conjugation of the ubiquitin protein (a small protein highly conserved among eukaryotes) to itself or to other proteins through differential use of ubiquitin’s seven internal linkage sites or the amino-terminal amino group ...
Abudu I. Bello, Rituparna Goswami, Shelby L. Brown, Kara Costanzo, Taylor Shores, Shefaa Allan, Revan Odah, Ryan D. Mohan   +7 more
doaj   +1 more source

DRJAMM Is Involved in the Oxidative Resistance in Deinococcus radiodurans

Frontiers in Microbiology, 2022
Proteins containing JAB1/MPN/MOV34 metalloenzyme (JAMM/MPN+) domains that have Zn2+-dependent deubiquitinase (DUB) activity are ubiquitous across among all domains of life.
Jianling Cai, Chaoming Pan, Ye Zhao, Hong Xu, Bing Tian, Liangyan Wang, Yuejin Hua   +6 more
doaj   +1 more source

Intermittent hypoxia-induced downregulation of microRNA-320b promotes lung cancer tumorigenesis by increasing CDT1 via USP37

Molecular Therapy: Nucleic Acids, 2021
Obstructive sleep apnea-hypopnea (OSAH) is correlated with an increased incidence of lung cancer. In our study, we explored the functional roles of microRNAs (miRNAs) in lung cancer patients that were complicated with OSAH involving the deubiquitination ...
Weihao Li, Kai Huang, Fengbiao Wen, Guanghui Cui, Haizhou Guo, Zhanfeng He, Song Zhao   +6 more
doaj   +1 more source

Listeria promotes systemic infection by targeting the host deubiquitinase CYLD. [PDF]

Nat Commun
Listeria monocytogenes ( Lm ) is an intracellular pathogen that can cause life-threatening systemic infections. Internalin C (InlC) is a secreted factor required for full Lm
Ammendolia DA, Ellison CJ, Zheng Y, Coyaud E, Laurent EMN, Yan BR, Manning B, Waldmann AK, Tan JMJ, Frendo-Cumbo S, Lyons C, Youn JY, Raught B, Ireton K, Higgins DE, Elliott PR, Brumell JH.   +16 more
europepmc   +2 more sources

Independent Inhibition of the Polymerase and Deubiquitinase Activities of the Crimean–Congo Hemorrhagic Fever Virus Full-Length L-Protein

Proceedings, 2020
The Crimean–Congo hemorrhagic fever virus (CCHFV) is a segmented negative-sense RNA virus that can cause severe human disease. The World Health Organization (WHO) has listed CCHFV as a priority pathogen with an urgent need for enhanced research ...
Egor P. Tchesnokov, Ben A. Bailey-Elkin, Brian L. Mark, Matthias Götte   +3 more
doaj   +1 more source

Ubiquitin-interacting motifs of ataxin-3 regulate its polyglutamine toxicity through Hsc70-4-dependent aggregation

eLife, 2020
Spinocerebellar ataxia type 3 (SCA3) belongs to the family of polyglutamine neurodegenerations. Each disorder stems from the abnormal lengthening of a glutamine repeat in a different protein. Although caused by a similar mutation, polyglutamine disorders
Sean L Johnson, Bedri Ranxhi, Kozeta Libohova, Wei-Ling Tsou, Sokol V Todi   +4 more
doaj   +1 more source

The pleiotropic deubiquitinase Ubp3 confers aneuploidy tolerance [PDF]

, 2018
Aneuploidy—or an unbalanced karyotype in which whole chromosomes are gained or lost—causes reduced fitness at both the cellular and organismal levels but is also a hallmark of human cancers.
Santaguida, Stefano, Kim, Sharon H., Dodgson, Stacie Elizabeth, Amon, Angelika B., Sheltzer, Jason   +4 more
core   +2 more sources

Role of CYLD deubiquitinase in myocardial infarction

, 2023
<p>CYLD is a deubiquitinase that preferentially removes lysine 63-linked polyubiquitin chains from its substrates, thus mainly regulating non-proteolytic cellular functions such as kinase activation, protein trafficking, and signal transduction ...
Liu, Qinghang
core   +1 more source