Results 21 to 30 of about 17,466 (191)
Dual function of the Leon/USP5 deubiquitinase in the ubiquitin-proteasome and autophagic pathways
Autophagy Reports, 2023 The ubiquitin-proteasome system (UPS) and autophagy are highly conserved processes that maintain cellular health through the clearance of misfolded/aberrant proteins and damaged organelles.
Yuchieh Jay Lin, Guang-Chao Chen
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Cezanne (OTUD7B) regulates HIF-1α homeostasis in a proteasome-independent manner [PDF]
, 2014 The transcription factor HIF-1α is essential for cells to rapidly adapt to low oxygen levels (hypoxia). HIF-1α is frequently deregulated in cancer and correlates with poor patient prognosis.
Anja Bremm +9 more
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Biomolecules, 2021 Dienone compounds with a 1,5-diaryl-3-oxo-1,4-pentadienyl pharmacophore have been widely reported to show tumor cell selectivity. These compounds target the ubiquitin-proteasome system (UPS), known to be essential for the viability of tumor cells.
Karthik Selvaraju +8 more
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A review of deubiquitinases and thier roles in tumorigenesis and development
Frontiers in Bioengineering and Biotechnology, 2023 Ubiquitin is a small protein that can be added onto target protein for inducing target degradation, thereby modulating the activity and stability of protein.
Xian-Wen Liang +8 more
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, 2021 S4. Refinement of the mechanism for ASXL stimulation of BAP deubiquitinase activity.
Kasirajan Ayyanathan (150785) +18 more
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A molecular sensor determines the ubiquitin substrate specificity of SARS-CoV-2 papain-like protease
Cell Reports, 2021 Summary: The SARS-CoV-2 papain-like protease (PLpro) is a target for antiviral drug development. It is essential for processing viral polyproteins for replication and functions in host immune evasion by cleaving ubiquitin (Ub) and ubiquitin-like protein (
Stephanie Patchett +6 more
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, 2015 Repair of DNA alkylation damage is critical for genomic stability and involves multiple conserved enzymatic pathways. Alkylation damage resistance, which is critical in cancer chemotherapy, depends on the overexpression of alkylation repair proteins ...
Nima Mosammaparast +11 more
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Preventing Necrosis by Cleaving a Deubiquitinase
, 2011 Cleavage of the deubiquitinase CYLD by caspase 8 prevents necrosis in response to the cytokine TNF.
Wei Wong
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In the Limelight: Ras, Ebola, Deubiquitinase, and Acetyl-CoA [PDF]
, 2014 Each month, Chemistry & Biology Select highlights a selection of research reports recently published in other journals. These highlights are a snapshot of interesting research done across the field of chemical biology, and this month's Select features a ...
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The Deubiquitinase OTUD1 Influences HIV-1 Release by Regulating the Host Restriction Factor BST-2
VirusesBone marrow stromal cell antigen 2 (BST-2) is a restriction factor for human immunodeficiency virus type I (HIV-1) and plays an important role in regulating the release of viral particles.
Man-Di Zhang +9 more
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