Research progress of OTUD7B: from structural function and disease mechanisms to clinical translation [PDF]
Frontiers in ImmunologyOTUD7B (Cezanne), a deubiquitinase of the Ovarian Tumor (OTU) domain family, regulates the ubiquitin-proteasome system and plays a role in maintaining cellular homeostasis. Its dysfunction is linked to the pathogenesis of multiple human diseases.
Qingsong Wang +9 more
doaj +2 more sources
Loss of CYLD on Chromosome 16q Impairs Homologous Recombination and Genomic Stability Through TIRR Degradation. [PDF]
Adv Sci (Weinh)Chromosome 16q loss drives genomic instability through disruption of the CYLD–TIRR–53BP1 axis. CYLD preserves homologous recombination by stabilizing TIRR and limiting 53BP1 accumulation at DNA double‐strand breaks. CYLD deficiency redirects repair toward error‐prone non‐homologous end joining, promotes mutational burden and homologous recombination ...
Lu M +14 more
europepmc +2 more sources
Functional Characterization of OTU Domain-Containing Deubiquitinases from Plant Pathogenic Fungi Reveals Distinct Immune Modulatory Mechanisms [PDF]
Journal of FungiUbiquitination is a key post-translational modification regulating cellular signaling and innate immunity, and its reversal by deubiquitinases (DUBs) represents a critical mechanism exploited by pathogens for immune evasion.
Sezer Akgöl +2 more
doaj +2 more sources
USP5 Stabilizes TGFBR1 to Drive Vascular Smooth Muscle Cell Senescence and Atherosclerosis. [PDF]
Adv Sci (Weinh)This study reveals that USP5 drives vascular smooth muscle cell senescence and atherosclerosis by stabilizing TGFBR1, suppressing IDH2, and promoting glycolytic reprogramming, identifying the USP5‐TGFBR1‐IDH2 axis as a potential therapeutic target. ABSTRACT Vascular smooth muscle cell (VSMC) senescence contributes importantly to atherosclerotic plaque ...
Cui X, Hu Y, Lin L, Zhang L, Li C, Li Y.
europepmc +2 more sources
USP25 stabilises GLI1 through K48-linked deubiquitination within a reciprocal regulatory circuit in osteoarthritis models. [PDF]
Clin Transl MedGLI1‐centred USP25‐GLI1 reciprocal regulation in OA‐relevant models. Hedgehog/GLI1 signalling transcriptionally reinforces USP25 expression, while USP25 deubiquitinates and stabilises GLI1. This reciprocal circuit is associated with inflammatory and cartilage‐catabolic changes in the tested models.
Zhang Q, Ye Y, Huang Y, Li J, Huang D.
europepmc +2 more sources
TgJosephin and TgRad23 are important for anti-IFN-γ virulence via deubiquitination of SPM1 in Toxoplasma [PDF]
mSphereToxoplasma gondii, which can virtually infect all warm-blooded cells, secretes various virulence factors to evade interferon-gamma (IFN-γ)-dependent host immunity. While these secreted proteins are widely characterized, the molecular mechanisms important
Emi Hashizaki +7 more
doaj +2 more sources
The role of OTUD1-mediated deubiquitination in disease pathogenesis: from molecular mechanisms to clinical translation [PDF]
Frontiers in ImmunologyOTUD1 is a deubiquitinase of the OTU family that participates in immune signaling, redox balance, and cell death through modulating substrate ubiquitination.
Qingsong Wang +5 more
doaj +2 more sources
Hepatology Communications, 2023 Background:. The role of thioredoxin-interacting protein (TXNIP) in lipopolysaccharide-induced liver injury in mice has been reported, but the underlying mechanisms are poorly understood. Methods:.
Songchang Shi +9 more
doaj +1 more source
USP39-Mediated Non-Proteolytic Control of ETS2 Suppresses Nuclear Localization and Activity
Biomolecules, 2023 ETS2 is a member of the ETS family of transcription factors and has been implicated in the regulation of cell proliferation, differentiation, apoptosis, and tumorigenesis.
Yunsik Choi +4 more
doaj +1 more source
Cancer Biology & Therapy, 2022 Cancer metastasis is a major cause of cancer-related mortality. Strategies to reduce metastases are needed especially in lung cancer, the most common cause of cancer mortality.
Zibo Chen +15 more
doaj +1 more source