Results 221 to 230 of about 27,539 (236)
Some of the next articles are maybe not open access.
Science's STKE, 2003
Ubiquitination is associated with targeting of proteins for degradation (polyubiquitination) or regulation (monoubiquitination). Chen et al. stimulated synaptosomes (pinched off nerve terminals enriched in presynaptic components from brain) with high K + to depolarize the membranes, which in ...
openaire +1 more source
Ubiquitination is associated with targeting of proteins for degradation (polyubiquitination) or regulation (monoubiquitination). Chen et al. stimulated synaptosomes (pinched off nerve terminals enriched in presynaptic components from brain) with high K + to depolarize the membranes, which in ...
openaire +1 more source
Enzymes of ubiquitination and deubiquitination
Essays in Biochemistry, 2012Ubiquitination, the covalent attachment of the small protein modifier ubiquitin to a substrate protein is involved in virtually all cellular processes by mediating the regulated degradation of proteins. Aside from proteasomal degradation, ubiquitination plays important roles in transcriptional regulation, protein trafficking, including endocytosis and ...
Neutzner, M., Neutzner, A.
openaire +3 more sources
Deubiquitinating Enzymes as Cellular Regulators
Journal of Biochemistry, 2003Modification of proteins by the covalent attachment of ubiquitin is a key regulatory mechanism of many cellular processes including protein degradation by the 26S proteasome. Deubiquitination, reversal of this modification, must also regulate the fate and function of ubiquitin-conjugated proteins.
Jung Hwa, Kim +4 more
openaire +2 more sources
Targeting Deubiquitinating Enzymes
2009Deubiquitinating enzymes (DUBs) or isopeptidases belong to the enzyme class of hydrolases which include more than 100 members identified thus far. These proteins, which are grouped into four cysteine protease families and one metallo-protease family, catalyze the removal of ubiquitin from specific protein targets by cleavage of the linking isopeptide ...
Carmen Priolo +3 more
openaire +1 more source
Strategies for Assaying Deubiquitinating Enzymes
2005A general method for assaying deubiquitinating enzymes (DUBs) has been developed. This new method employs an indirect enzyme assay for determining the activity of DUBs using a linear fusion of polyHis-glutathione-S-transferase-ubiquitin-ecotin (His-GST-Ub-ecotin) as a substrate. Because ecotin, a trypsin inhibitor protein from Escherichia coli, is heat
Sung Hwan, Kang +4 more
openaire +2 more sources
1998
As detailed elsewhere in this volume, modification of proteins by the 76-residue ubiquitin polypeptide is involved in many aspects of protein metabolism. Among the cellular processes affected by ubiquitin-dependent reactions are chromosome structure and segregation, cell-cycle progression, receptor-mediated signal transduction, gene expression, protein
Keith D. Wilkinson, Mark Hochstrasser
openaire +1 more source
As detailed elsewhere in this volume, modification of proteins by the 76-residue ubiquitin polypeptide is involved in many aspects of protein metabolism. Among the cellular processes affected by ubiquitin-dependent reactions are chromosome structure and segregation, cell-cycle progression, receptor-mediated signal transduction, gene expression, protein
Keith D. Wilkinson, Mark Hochstrasser
openaire +1 more source
Dysregulation of deubiquitination in breast cancer
GeneBreast cancer (BC) is a highly frequent malignant tumor that poses a serious threat to women's health and has different molecular subtypes, histological subtypes, and biological features, which act by activating oncogenic factors and suppressing cancer inhibitors.
Lili Kong, Xiaofeng Jin
openaire +2 more sources
214: The deubiquitinating enzyme USP15 deubiquitinates the E3 ligase SMURF2
European Journal of Cancer, 2014P. Iyengar, P. Jaynes, P. Eichhorn
openaire +1 more source