Results 31 to 40 of about 273,322 (239)

Stoichiometric and Catalytic Deuterium and Tritium Labeling of “Unactivated” Organic Substrates with Cationic Ir(III) Complexes

, 2016
Ir(III) complex [Cp*(PMe3)IrMe(CH2Cl2)][BArf] (1) was used to introduce deuterium stoichiometrically into substituted naphthalene/benzene templates and several “druglike” entities.
Robert G. Bergman (1323120), Cathleen M. Yung (2508334), Marc B. Skaddan (1947523)   +2 more
core   +1 more source

Metabolic Deuterium Oxide Labeling for Quantitative Lipidomics

, 2023
Quantitative analysis of lipid changes between normal and disease states plays a pivotal role in unraveling the underlying pathophysiology and identifying potential biomarkers associated with lipid metabolism-related diseases.
Kim, Jonghyun, Goh, Byoungsook, Kim, Tae-Young, Seo, Seungwoo   +3 more
core  

Time course trajectory of triacylglycerol TG(16∶0/18∶2/20∶4)[iso6] without any deuterium labeling in liver samples.

, 2013
Time course trajectory of triacylglycerol TG(16∶0/18∶2/20∶4)[iso6] without any deuterium labeling in liver samples.
Xiang Zhang (19800), Wenlong Sun (284779), Yunan Tang (284778), Xiaoli Wei (192481), Yantao Zhao (284776), Craig McClain (144590), Xue Shi (284772), Wei Zhong (284774), Xinmin Yin (284781), Seongho Kim (284788), Zhanxiang Zhou (284791), Bogdan Bogdanov (284784)   +11 more
core   +1 more source

Sertraline Treatment Can Mimic Niemann‐Pick Type C Biomarker Profile: A Diagnostic Pitfall

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Oxysterols (cholestane‐3β,5α,6β‐triol and 7‐ketocholesterol) and N‐palmitoyl‐O‐phosphocholineserine (PPCS) are sensitive biomarkers for Niemann‐Pick disease type C (NPC) screening. However, false‐positive results occur, with a biomarker profile suggestive of NPC despite the absence of pathogenic variants in genes involved in NPC or ...
Maria Makrygianni, Cecile Pagan, Antony Citterio‐Quentin, Isabelle Rouvet, Giulia Dingeo, Cyril Hanin, Claudine Laurent‐Levinson, Samia Pichard, Bénédicte Héron, Clément Gourguechon, Daniele Mandia, Jerome Guitton, Carole Lacout, Nicolas Schleinitz, Florient Potier, Olivier Flabeau, Elsa Besse‐Pinot, Foudil Lamari, Magali Pettazzoni, Yann Nadjar   +19 more
wiley   +1 more source

Cryogenic Deformation Behavior of TiAl and Insights Into Embrittlement After High‐Temperature Exposure Combined With Secondary Ion Mass Spectroscopy of Near Surface Chemistry

Advanced Engineering Materials, EarlyView.
Near‐surface deuterium enrichment profiles for different microstructural types of TiAl after exposure at 700 °C in a heavy water‐containing environment. The deuterium levels are significantly higher than expected from natural occurrence, indicating that the heavy water dissociated during the exposure treatment and entered the specimens.
Jonathan D. H. Paul, Alexander Welle, Dirk Matthiessen, Michael Oehring, Fritz Appel, Florian Pyczak   +5 more
wiley   +1 more source

Chronic alcohol exposure disturbs lipid homeostasis at the adipose tissue-liver axis in mice: analysis of triacylglycerols using high-resolution mass spectrometry in combination with in vivo metabolite deuterium labeling.

PLoS ONE, 2013
A method of employing high-resolution mass spectrometry in combination with in vivo metabolite deuterium labeling was developed in this study to investigate the effects of alcohol exposure on lipid homeostasis at the white adipose tissue (WAT)-liver axis
Xiaoli Wei, Xue Shi, Wei Zhong, Yantao Zhao, Yunan Tang, Wenlong Sun, Xinmin Yin, Bogdan Bogdanov, Seongho Kim, Craig McClain, Zhanxiang Zhou, Xiang Zhang   +11 more
doaj   +1 more source

In Situ Interfacial Assembly of Dynamic Semi‐Interpenetrating Biopolymer Networks for Robust and Mechanically Adaptive Droplet Interfaces

Advanced Functional Materials, EarlyView.
A dynamic interfacial semi‐interpenetrating polymer network is constructed by sequential assembly of β‐sheet‐rich SF and CS‐RL. The SF framework provides mechanical strength, while dynamically associated CS‐RL enables local rearrangement, allowing droplets to rapidly reconfigure without loss of interfacial integrity.
Yaping Zhang, Yujie Liu, Yikai Xu, Xunda Feng, Ling Zhang, Hongbo Zeng, Hao Liu, Xiaohui Mao   +7 more
wiley   +1 more source

Mechanochemical Dehalogenative Deuteration of Alkyl Halides Through Piezoelectric Catalysis Initiated by a Single‐Electron Oxidation Strategy

Advanced Science
Deuterium labeling is extensively utilized across various scientific disciplines. The dehalogenative deuteration of organic halides offers a promising approach for achieving deuterium labeling.
Ruiling Qu, Ruoxuan Liu, Xiaochun He, Xuemei Zhang, Zhong Lian   +4 more
doaj   +1 more source

The Role of Viscoelasticity in Heterogeneous Glioblastoma Stem Cell Invasion in Biomimetic 3‐Dimensional Hydrogels

Advanced Healthcare Materials, EarlyView.
The role of viscoelasticity in the invasion of heterogeneous glioblastoma stem cells (GSCs) was investigated with GSCs categorized into subgroups based on molecular profile, as Reactive, Invasive, or Constructive using viscoelastic biomimetic hyaluronan‐oxime hydrogels.
Nicole J. Blaine, Arianna Skirzynska, Allysia A. Chin, Julie Audet, Molly S. Shoichet   +4 more
wiley   +1 more source

Photocatalyst-free photochemical deuteration via H/D exchange with D2O

Nature Communications
Deuterium labeling is increasingly important across scientific fields, from drug development to materials engineering, but current methods often require expensive catalysts.
Ying Meng, Bei Shu, Jing Zhang, Heng Rao, Ziyuan Zhou, Zhiyuan Wang, Zhongyi Liu, Kangdong Liu, Yueteng Zhang, Wei Wang   +9 more
doaj   +1 more source