Results 131 to 140 of about 869,633 (359)
The empirical relevance of minimum wages for the low-wage sector [PDF]
Niedriglohn, Mindestlohn, Wirtschaftlichkeit, Arbeitsplatz, Deutschland, Low wages, Minimum wage, Economic effectiveness, Job ...
Joachim Ragnitz, Marcel Thum
core
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
The Impact of Environmental Regulation on Competitiveness in the European Cement Industry - Results of a Matched Plant Comparison between Germany, Spain and the UK [PDF]
Zementindustrie, Umweltauflage, Internationaler Wettbewerb, Vergleich, EU-Staaten, Großbritannien, Spanien, Deutschland, Cement industry, Environmental regulation, Global competition, Comparison, EU countries, United Kingdom, Spain ...
D. Hitchens, Ursula Triebswetter
core
The impact of European integration on the German system of pharmaceutical product authorization [PDF]
, 2008 The European Union has evolved since 1965 into an influential political player in the regulation of pharmaceutical safety standards. The objective of establishing a single European market for pharmaceuticals makes it necessary for member-states to adopt ...
Schmucker, Rolf
core
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Do Strict Electoral Campaign Finance Rules Limit Corruption? [PDF]
Wahlkampffinanzierung, Parteienfinanzierung, Korruption, Österreich, Frankreich, Deutschland, Japan, , Vereinigte Staaten, Campaign finance, Party finance, Corruption, Austria, France, Germany, United ...
Thomas Stratmann
core
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
From small business promotion to creating an entrepreneurial society [PDF]
Mittelstandspolitik, Unternehmer, Wissenstransfer, EU-Staaten, Deutschland, Small business policy, Entrepreneurs, Knowledge transfer, EU countries ...
David B. Audretsch
core
Zur empirischen Analyse langer Zyklen wirtschaftlicher Entwicklung in Deutschland: Datenbasis und Berechnungsmethoden [PDF]
, 2011 Das vorliegende Arbeitspapier stellt Datenbasis und Berechnungsmethoden für den Kieler Diskussionsbeitrag Nr. 55 dar, der sich mit dem Phänomen und den Ursachen langfristiger Wachstumszyklen im Gebiet der Bundesrepublik Deutschland befaßt.
Glismann, Hans H. +2 more
core
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source