Results 151 to 160 of about 465,086 (310)

Fakten, Daten, Namen [PDF]

, 1998
Solvay Deutschland GmbH
core  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Europa-Union-Dienst Presseinformationen u. Kommentare [PDF]

, 1963
Europa-Union Deutschland
core  

Erratum zu: Wirkungen der Beteiligung und Partizipation von Bürger:innen in Erkenntnisprozessen der integrierten kommunalen Gesundheitsförderung. Ein systematischer Scoping-Review. [PDF]

Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz
Hartung S, Houwaart S, von Rüden U, Schaefer I.   +3 more
europepmc   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Keren Tora Wa'awoda für Deutschland 1940 [PDF]

Documents (telegram, Chanukah program from 1935, flyer promoting youth kibbutz in Eretz Israel) from the Keren Tora Wa'awoda für Deutschland. This organization had a school in Tel Aviv called "Tachkemoni".Processed for digitizationSent for ...
Taḥkemoni (School : Tel Aviv, Israel), Keren Tora Wa'awoda für Deutschland   +1 more
core  

[Characterization of imported dengue fever cases in Germany - Results of a pilot project]. [PDF]

Dtsch Med Wochenschr
Wintel M, Bernhard J, Beck JS, Fuchs A, Tobian F, Lindner AK, Mockenhaupt FP, Denkinger CM.   +7 more
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Einfluss der Agenda 2030 auf die deutschsprachige Bibliothekswelt

Library Ideas, 2020
Franziska Corradini
doaj   +1 more source