Results 151 to 160 of about 953,705 (390)
Molecular Oncology, EarlyView.A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He +8 more
wiley +1 more source
, 1886 Umschau in Heimat und Fremde: ein geographisches Lesebuch zur Ergänzung der Lehrbücher der Geographie, insonderheit derer von Ernst v.
openaire +3 more sources
Steuerliche Familienförderung in Frankreich und Deutschland
, 2005 Ein Vergleich der Umverteilungswirkungen der steuerlichen Familienförderung in Deutschland und Frankreich auf Basis von Mikrodaten zeigt, dass die Umverteilung in Deutschland eine größere Dimension hat als in Frankreich.
Baclet, Alexandre +2 more
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Einseitige Exportorientierung belastet Wachstum: Frankreich besser als Deutschland [PDF]
, 2010 Die Vorwürfe der französischen Finanzministerin Christine Lagarde, Deutschland fördere seine Exporte durch geringe Lohnzuwächse auf Kosten der anderen Länder des Euroraumes, wurden in Deutschland weitgehend mit Empörung aufgenommen.
Horn, Gustav A. +2 more
core
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
German banks and industrial finance in the 1990s [PDF]
This paper examines the role of the banking system in the German model ofindustrial development. It argues that the banks continue to fulfill several of theirtraditional functions in industrial finance, despite dramatic changes in financial regulation ...
Deeg, Richard
core
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source