Results 51 to 60 of about 38,920 (244)

„Grundstein für Weiterentwicklung von Gesundheitsystemen”

Monitor Versorgungsforschung
Prof. Dr. Oliver Gröne, Chief Scientific Officer und Leiter Forschung der OptiMedis AG sowie Mitglied des PaRIS-SUR-Konsortiums, geht davon aus, dass der OECD-Initiative „Patient-Reported Indicator Survey” (PaRIS) eine ähnliche Bedeutung wie das OECD ...
Prof. Dr. Oliver Gröne PhD MSc, Peter Stegmaier   +1 more
doaj   +1 more source

Deutschland Deutschland über alles

, 2022
»Deutschland, Deutschland über alles«: Zitat aus dem Refrain des Lieds der Deutschen (Deutschlandlied). Text: August Heinrich Hoffmann von Fallersleben (1841), Musik: Joseph Haydn. Die Melodie stammt ursprünglich aus dem 1797 entstandenen Kaiserlied Haydns, der offiziellen Volkshymne Gott erhalte Franz, den Kaiserfür den damaligen römisch-deutschen ...
Straub, Wolfgang, Dürr, Claudia, Raunig, Elisabeth   +2 more
openaire   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Das Endoprothesenregister Deutschland (EPRD) – Versorgungsrealität in Deutschland

, 2017
Deutscher Kongress für Orthopädie und Unfallchirurgie (DKOU 2017)
Steinbrück, A, Melsheimer, O, Liebs, T, Grimberg, A, Jansson, V   +4 more
openaire   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

INWIEFERN WIRKT SICH ARBEITSLOSIGKEIT IN BEZUG AUF DIE PARTIZIPATION AM BEISPIEL DER KOMMUNALWAHLEN AM 25.05.2014 IN DORTMUND AUS?

RUDN Journal of Public Administration, 2016
Im Artikel wird wenig besprochenes in deutscher wissenschaftlicher Literatur Problem der Verbindung zwischen Arbeitslosigkeit und der sozialen Aktivitt der Bundesbrger betrachtet.
Evgenia E Koppel, Galina I Bykova
doaj   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source