Results 61 to 70 of about 878,178 (411)
Wissenschaftsskepsis als doppelte Ausschlusserfahrung während der Corona-Pandemie. Eine bildungssoziologisch-politikwissenschaftliche Perspektive mit Pierre Bourdieu [PDF]
Magazin erwachsenenbildung.atDer Beitrag erklärt, basierend auf der Theorie Pierre Bourdieus, den empirisch belegbaren Zusammenhang zwischen formal niedrigem Bildungsabschluss, Misstrauen gegen die Wissenschaft und dem Wählen von sich als „wissenschaftsskeptisch“ inszenierenden ...
Lukas Hofmann
doaj
FEBS Letters, EarlyView.Three‐dimensional (3D) biological systems have become key tools in lymphoma research, offering reliable in vitro and ex vivo platforms to explore pathogenesis and support precision medicine. This review highlights current 3D non‐Hodgkin lymphoma models, detailing their features, advantages, and limitations, and provides a broad perspective on future ...
Carla Faria +3 more
wiley +1 more source
The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1
FEBS Letters, EarlyView.MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson +7 more
wiley +1 more source
FEBS Letters, EarlyView.Tuberculosis remains a global health challenge and new therapeutic targets are required. Here, we characterized SseA, a sulfurtransferase from Mycobacterium tuberculosis involved in macrophage infection, and its interaction with the newly identified protein SufEMtb that activates SseA enzymatic activity.
Giulia Di Napoli +10 more
wiley +1 more source
Aβ42 promotes the aggregation of α‐synuclein splice isoforms via heterogeneous nucleation
FEBS Letters, EarlyView.The aggregation of amyloid‐β (Aβ) and α‐synuclein (αSyn) is associated with Alzheimer's and Parkinson's diseases. This study reveals that Aβ aggregates serve as potent nucleation sites for the aggregation of αSyn and its splice isoforms, shedding light on the intricate interplay between these two pathogenic proteins.
Alexander Röntgen +2 more
wiley +1 more source
ERBIN limits epithelial cell plasticity via suppression of TGF‐β signaling
FEBS Letters, EarlyView.In breast and lung cancer patients, low ERBIN expression correlates with poor clinical outcomes. Here, we show that ERBIN inhibits TGF‐β‐induced epithelial‐to‐mesenchymal transition in NMuMG breast and A549 lung adenocarcinoma cell lines. ERBIN suppresses TGF‐β/SMAD signaling and reduces TGF‐β‐induced ERK phosphorylation.
Chao Li +3 more
wiley +1 more source
Freiwilliges Engagement in Deutschland
Empirische Studien zum bürgerschaftlichen Engagement, 2022 J. Simonson, C. Vogel, C. Tesch-Römer
semanticscholar +1 more source
The Jabal Akhdar Dome in the Oman Mountains : evolution of a dynamic fracture system [PDF]
, 2014 Acknowledgments: This study was carried out within the framework of DGMK (German Society for Petroleum and Coal Science and Technology) research project 718 “Mineral Vein Dynamics Modelling,” which is funded by the companies ExxonMobil Production ...
Arndt, M. +9 more
core +2 more sources
FEBS Letters, EarlyView.In this work, we reveal how different enzyme binding configurations influence the fluorescence decay of NAD(P)H in live cells using time‐resolved anisotropy imaging and fluorescence lifetime imaging microscopy (FLIM). Mathematical modelling shows that the redox states of the NAD and NADP pools govern these configurations, shaping their fluorescence ...
Thomas S. Blacker +8 more
wiley +1 more source
Convivium, 2010 Der Text ist ein Versuch, die gegenwärtige österreichische Prosa von Frauen im Spiegel feministischer Konzepte zu zeigen. Besondere Aufmerksamkeit gilt dabei den andersgearteten Entwicklungen in Österreich und in Deutschland.
Joanna Drynda
doaj +1 more source