Results 121 to 130 of about 4,484,193 (288)

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Generating and flattening developable surfaces

, 1994
In this paper, methods for generating and flattening developable surfaces by means of two given directrix curves have been investigated. By finding the two end points of every generatrix, a developable surface may be formed.
Tan, ST, Gan, MC, Chan, KW
core  

On the developable ruled surfaces Kinematically generated in Minkowski 3-Space

Kuwait Journal of Science, 2014
In this paper, we present a method to be developable of a ruled surface, generated in Minkowski 3-space R corresponding to the dual Lorentzian curves according to E. Study's transference principle and some theorems and examples.
HACI BAYRAM KARADAg١, EROL KILIC, MUGEKAR ADAg١   +2 more
doaj  

Novel Geometric Construction Methods and Application for Embankment Surface

Axioms
Embankments are extensively applied in civil engineering and exist naturally, characterized by a constant slope ensuring stable material stacking. Despite their ubiquity, research on embankment surface geometric modeling remains limited.
Fangxiao Zhou, Zhiming Zou, Gang Wang, Jingshun Chen   +3 more
doaj   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Poisson Developable Surfaces

, 2005
Recurring to some excellent geometric and algebraic properties of Poisson curves, we present an algorithm that generates a developable Poisson surface through a Poisson curve of arbitrary degree.
Xingwang Zhang, Guojin Wang
core  

Flattening developable bi-parametric surfaces

, 1996
This paper describes a computer method for transforming an arbitrary developable surface into a flattened pattern. Developable surfaces are a special class of ruled surfaces. The Gaussian curvature of any point of the developable surfaces is zero.
Tan, ST, Gan, MC, Chan, KW
core   +1 more source

On the method of determination of a developable timelike ruled surface

, 2012
A method of determination of a developable ruled surface is given by Kose. In this paper, first we have obtained the parametric equations of dual hyperbolic and Lorentzian unit spheres (DHUS) H-0(2+) and (DLUS) S-1(2) and then presented a method of ...
ÖZÜSAĞLAM, ERDAL, EKİCİ, CUMALİ
core   +1 more source