Results 141 to 150 of about 23,042,479 (320)
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
On the developable surfaces. [IV.] [PDF]
Časopis pro pěstování matematiky a fysiky, 1880 openaire +4 more sources
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Industrial design using interpolatory discrete developable surfaces
, 2011 Design using free-form developable surfaces plays an important role in the manufacturing industry. Currently most commercial systems can only support converting free-form surfaces into approximate developable surfaces.
Wu, Tie Ru +7 more
core +1 more source
Novel Geometric Construction Methods and Application for Embankment Surface
AxiomsEmbankments are extensively applied in civil engineering and exist naturally, characterized by a constant slope ensuring stable material stacking. Despite their ubiquity, research on embankment surface geometric modeling remains limited.
Fangxiao Zhou +3 more
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
POSITION VECTOR OF A DEVELOPABLE q-SLANT RULED SURFACE
In this paper, we study the position vector of a developable q-slant ruled surface in the Euclidean 3-space E-3 in means of the Frenet frame of a q-slant ruled surface.
Önder, M, Kaya, O
core
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
On the method of determination of a developable timelike ruled surface
, 2012 A method of determination of a developable ruled surface is given by Köse. In this paper, first we have obtained the parametric equations of dual hyperbolic and Lorentzian unit spheres (DHUS) H2+ 0 and (DLUS) S1 2 and then presented a method of ...
Özüsağlam, Erdal, Ekici, Cumali
core