Results 71 to 80 of about 4,484,193 (288)
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Developable Surface Fitting to Point Clouds Abstract
, 2008 Given a set of data points as measurements from a developable surface, the present paper investigates the recognition and reconstruction of these objects.
Martin Peternell
core
Developable surface processing methods for three-dimensional meshes
, 2006 Developable surfaces are of great significance in computer graphics as they play a key role in many applications involving planar surface parameterization.
Julius, Dan Natan
core +1 more source
Methods for Creating Curved Shell Structures From Sheet Materials
Buildings, 2012 This paper describes some methods for producing developable surfaces with practical applications for creating useful lightweight, rigid, jig-less and elegant structural forms from sheet materials. Multiple related techniques based on the same fundamental
Bruno Postle
doaj +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
On The Darboux Frame Motion of a Developable Surface
, 2021 Developable ruled surfaces and the rotation-minimizing frames (RMF) have a crucial importance in computer-aided geometric design (CAGD) because of being unfoldable (developable) into a plane without distortion.
Çalışkan, Ali, Bulut, Vahide
core
Developable Surface Segmentation for CAD Models via Sparse Normal Discontinuity Detection
MathematicsSegmenting CAD models into developable surface patches is a fundamental problem in geometric modeling and manufacturing-oriented applications. Existing approaches often rely on discrete Gaussian curvature estimation or Gauss map analysis; however, their ...
Linlin Xu +4 more
doaj +1 more source
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source